Home >> Research Area >>Tyrosine Kinase/Adaptors>>VEGFR>> (E)-FeCP-oxindole

(E)-FeCP-oxindole

Selective VEGFR-2 inhibitor CAS# 884338-18-5

(E)-FeCP-oxindole

Catalog No. BCC6078----Order now to get a substantial discount!

Product Name & Size Price Stock
(E)-FeCP-oxindole: 5mg $150 In Stock
(E)-FeCP-oxindole: 10mg Please Inquire In Stock
(E)-FeCP-oxindole: 20mg Please Inquire Please Inquire
(E)-FeCP-oxindole: 50mg Please Inquire Please Inquire
(E)-FeCP-oxindole: 100mg Please Inquire Please Inquire
(E)-FeCP-oxindole: 200mg Please Inquire Please Inquire
(E)-FeCP-oxindole: 500mg Please Inquire Please Inquire
(E)-FeCP-oxindole: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of (E)-FeCP-oxindole

Number of papers citing our products

Chemical structure

(E)-FeCP-oxindole

3D structure

Chemical Properties of (E)-FeCP-oxindole

Cas No. 884338-18-5 SDF Download SDF
PubChem ID 124080971 Appearance Powder
Formula C19H15FeNO M.Wt 329.17
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 5 mM in DMSO
Chemical Name cyclopentane;(3E)-3-(cyclopentylmethylidene)-1H-indol-2-one;iron(2+)
SMILES C1CCCC1.C1CCC(C1)C=C2C3=CC=CC=C3NC2=O.[Fe+2]
Standard InChIKey JGKCUURLEMXRGX-ANOGCNOSSA-N
Standard InChI InChI=1S/C14H15NO.C5H10.Fe/c16-14-12(9-10-5-1-2-6-10)11-7-3-4-8-13(11)15-14;1-2-4-5-3-1;/h3-4,7-10H,1-2,5-6H2,(H,15,16);1-5H2;/q;;+2/b12-9+;;
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of (E)-FeCP-oxindole

DescriptionSelective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM. Geometric isomer of (Z)-FeCP-oxindole.

(E)-FeCP-oxindole Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

(E)-FeCP-oxindole Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of (E)-FeCP-oxindole

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0379 mL 15.1897 mL 30.3794 mL 60.7589 mL 75.9486 mL
5 mM 0.6076 mL 3.0379 mL 6.0759 mL 12.1518 mL 15.1897 mL
10 mM 0.3038 mL 1.519 mL 3.0379 mL 6.0759 mL 7.5949 mL
50 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.2152 mL 1.519 mL
100 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.6076 mL 0.7595 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on (E)-FeCP-oxindole

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors.[Pubmed:21359402]

Metallomics. 2011 Jun;3(6):600-8.

(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

Keywords:

(E)-FeCP-oxindole,884338-18-5,Natural Products,VEGFR, buy (E)-FeCP-oxindole , (E)-FeCP-oxindole supplier , purchase (E)-FeCP-oxindole , (E)-FeCP-oxindole cost , (E)-FeCP-oxindole manufacturer , order (E)-FeCP-oxindole , high purity (E)-FeCP-oxindole

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: