(E)-FeCP-oxindoleSelective VEGFR-2 inhibitor CAS# 884338-18-5 |
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Quality Control & MSDS
3D structure
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| Cas No. | 884338-18-5 | SDF | Download SDF |
| PubChem ID | 124080971 | Appearance | Powder |
| Formula | C19H15FeNO | M.Wt | 329.17 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 5 mM in DMSO | ||
| Chemical Name | cyclopentane;(3E)-3-(cyclopentylmethylidene)-1H-indol-2-one;iron(2+) | ||
| SMILES | C1CCCC1.C1CCC(C1)C=C2C3=CC=CC=C3NC2=O.[Fe+2] | ||
| Standard InChIKey | JGKCUURLEMXRGX-ANOGCNOSSA-N | ||
| Standard InChI | InChI=1S/C14H15NO.C5H10.Fe/c16-14-12(9-10-5-1-2-6-10)11-7-3-4-8-13(11)15-14;1-2-4-5-3-1;/h3-4,7-10H,1-2,5-6H2,(H,15,16);1-5H2;/q;;+2/b12-9+;; | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM. Geometric isomer of (Z)-FeCP-oxindole. |
(E)-FeCP-oxindole Dilution Calculator
(E)-FeCP-oxindole Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0379 mL | 15.1897 mL | 30.3794 mL | 60.7589 mL | 75.9486 mL |
| 5 mM | 0.6076 mL | 3.0379 mL | 6.0759 mL | 12.1518 mL | 15.1897 mL |
| 10 mM | 0.3038 mL | 1.519 mL | 3.0379 mL | 6.0759 mL | 7.5949 mL |
| 50 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.2152 mL | 1.519 mL |
| 100 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.6076 mL | 0.7595 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors.[Pubmed:21359402]
Metallomics. 2011 Jun;3(6):600-8.
(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.
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