AMPK
AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α - (catalytic) and β /γ - (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.
Products for AMPK
- Cat.No. Product Name Information/Activity
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BCC4361
Dorsomorphin 2HCl
Dorsomorphin dihydrochloride (Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy.
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BCC5745
SAMS Peptide
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
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BCC2080
A-769662
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.
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BCC3606
AICAR
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy and mitophagy inhibitor.
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BCN5304
Cryptotanshinone
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
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BCC4799
Metformin HCl
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.
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BCC7846
PT 1
AMPK activator
