IαB Kinase
Iκ B Kinase (IKK) is an enzyme complex that forms part of the NF-κ B signaling pathway. The IKK complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α - and β -subunits are catalytically active whereas the γ -subunit has a regulatory function.
Products for IαB Kinase
- Cat.No. Product Name Information/Activity
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BCC6223
ACHP
406208-42-2
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BCC1423
BMS-345541
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
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BCC6130
PF 184
1187460-81-6
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BCC7949
PS 1145 dihydrochloride
1049743-58-9
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BCC4554
SC-514
SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
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BCC2473
TPCA-1
TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.
