Phosphoinositide-dependent Kinase 1
Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDPK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to growth factors and insulin signaling.
Products for Phosphoinositide-dependent Kinase 1
- Cat.No. Product Name Information/Activity
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BCC1813
NVP-BAG956
NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
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BCC3635
BX795
BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy.
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BCC4982
GSK2334470
GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.
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BCC1255
OSU-03012 (AR-12)
PDPK1 (PDK1) inhibitor; inhibits Akt signaling,OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.
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BCC2554
PHT-427
PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively.
