Janus N-terminal Kinase
JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.
Products for Janus N-terminal Kinase
- Cat.No. Product Name Information/Activity
-
BCC8088
AEG 3482
63735-71-7
-
BCC8089
BI 78D3
BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM).
-
BCC7982
CEP 1347
156177-65-0
-
BCC8085
c-JUN peptide
610273-01-3
-
BCC8093
IQ 3
312538-03-7
-
BCC5777
JIP-1 (153-163)
438567-88-5
-
BCC2474
SP 600125
JNK inhibitor; prevents BMP9-induced osteogenic differentiation of MSCs,SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
-
BCC7999
SR 3576
1164153-22-3
-
BCC7725
SU 3327
SU3327 is a potent, selective and substrate-competitive JNK inhibitor with an IC50 of 0.7 μM. SU3327 also inhibits protein-protein interactions between JNK and JNK Interacting Protein (JIP) with an IC50 of 239 nM. SU3327 shows less active against p38α and Akt kinase.
-
BCC5148
TCS JNK 5a
TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
