Calcium-Sensitive Protease Modulators
Calpain and cathepsin are calcium-sensitive proteases. Calpains are a family of 14 cysteine proteases that are involved in a range of cellular processes. Cathepsins are lysosomal calcium-sensitive proteases that have a key role in cellular protein turnover.
Products for Calcium-Sensitive Protease Modulators - Page 2
- Cat.No. Product Name Information/Activity
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BCC2353
PD 150606
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective.
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BCC2362
SID 26681509
SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G.
