BCC6461
KPT-9274
KPT-9274 is an inhibitor of p21-activated kinase (<b>PAK</b>) extracted from patent WO 2015003166 A1; has an <b>IC<sub>50</sub></b> of less than 100 nM in MTT assay.
BCC1853
PF-3758309
PF-3758309 is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation.
