BCC3912
CP-466722
CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 4.1 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.
BCC1389
AZ20
AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).
BCC6505
AZD6738
AZD6738 is a potent inhibitor of <b>ATR</b> kinase with an <b>IC<sub>50</sub></b> of 1 nM.
BCC2475
KU 55933
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
BCC3911
CGK733
CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.
BCC3699
KU-60019
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.
