Products with Anti-allergy bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5535 | Mangiferin |
| Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin has anti-steatotic , anti-cancer, anthelminthic and antiallergic activities, it has beneficial effect on the regulation of endothelial homeostasis and could be used in the management of diabetic cardiovascular complications. Mangiferin regulates proliferation and apoptosis in glioma cells by induction of miR-15b and inhibition of MMP-9 expression, it attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-κB and ERK. | |
| BCN5549 | Astragalin |
| Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity, it inhibits the TLR4-mediated NF-κB and mitogen-activated protein kinases signaling pathways. Astragalin ameliorates oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling; it also can be effective in allaying ROS-promoted bronchial fibrosis through inhibiting autophagosome formation in airways. | |
| BCN5560 | Acacetin |
| Acacetin is an atrium-selective agent that prolongs the atrial effective refractory period without prolonging the corrected QT interval and effectively prevents atrial fibrillation (AF) in anesthetized dogs after intraduodenal administration. Acacetin has anti-cancer, anti-mutagenic, spasmolytic and antinociceptive, anti-inflammatory and anti-peroxidative effects. | |
| BCN5561 | Hydrangenol |
| 1. Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae). 2. Hydrangenol can significantly inhibit the passive cutaneous anaphylaxis (PCA) reaction, it has antiallergic activity. 3. Hydrangenol has anti-inflammatory activity,it can attenuate NO production and inducible NO synthase expression in lipopolysaccharide (LPS)-stimulated BV2 microglial cells by inhibiting NF-κB activation and by stimulating the Nrf2-mediated HO-1 signaling pathway. 4. Hydrangenol has antifungal activity. | |
| BCN5566 | Citreorosein |
| 1. Citreorosein is a cAMP phosphodiesterase inhibitor. 2. Citreorosein has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation. 3. Citreorosein attenuates degranulation and LTC(4) generation through the suppression of multiple step signaling and would be beneficial for the prevention of allergic inflammation. 4. Citreorosein strongly inhibits COX-2-dependent PGD2 generation in a concentration-dependent manner in mouse bone marrow-derived mast cells (BMMCs) stimulated with stem cell factor (SCF)/IL-10/LPS. | |
