Products with Anti-osteoarthritis bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2248 | Astaxanthin |
| Astaxanthin is a strong antioxidant which shows neuroprotective property and can reduce the markers of inflammation, it can reduce matrix metalloproteinase expression in human chondrocytes, it may be beneficial in the treatment of osteoarthritis.Astaxanthin has protective effect on fetal alcohol spectrum disorder, and suggests that oxidative stress and TLR4 signaling associated inflammatory reaction are involved in this process. Astaxanthin administration can reduce renal calcium oxalate crystal deposition possibly by modulating the renal renin-angiotensin system (RAS), which reduces the expression of OPN and TGF-β1 levels. | |
| BCN2395 | Sclareol |
| Sclareol possesses anti-cancer, anti-osteoarthritic, immune-regulation and anti-inflammatory activities, it inhibits the MMPs, iNOS and COX-2 expression on mRNA and protein levels, while increases the TIMP-1 expression, and over-production of NO and PGE2 is also suppressed by Sclareol ameliorated cartilage degradation. Sclareol induces plant resistance to root-knot nematode partially through ethylene-dependent enhancement of lignin accumulation. | |
| BCN2481 | Farrerol |
| Farrerol has antioxidative, anti-bacterial, anti-inflammatory, antiangiogenic activities, it is a potential candidate for the intervention of endothelial-injury-associated cardiovascular diseases. Farrerol inactivates KEAP-1 or activates the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduces the intracellular production of reactive oxygen species via the induction of HO-1 expression. Farrerol can inhibit angiogenesis through down regulation of Akt/mTOR, Erk and Jak2/Stat3 signal pathway, and can inhibit IL-1β-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-κB signaling pathway. | |
| BCN2568 | Mevastatin |
| Mevastatin inhibits HMGCR (HMG-CoA reductase) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin inhibits the differentiation of TAO derived orbital preadipocytes by blocking PPAR-gamma mRNA expression. Mevastatin induces cell growth inhibition and apoptosis in SACC cells, it triggers the phosphorylation of the EGFR and inhibits the c-Jun N-terminal kinase pathway. | |
| BCN2989 | Hinokiflavone |
| Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9. | |
