Products with Antiangiogenic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3163 | Salvicine |
| 1. Salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. 2. Specificity of Salvicine and diversity of anticancer agents in the mechanism of interference with telomerase and the telomere system. 3. Salvicine has potent anti-angiogenic activity through the inhibition on the sequential angiogenic cascades: proliferation, migration and tube formation and is associated with influence on the expression of bFGF of tumor cell. 4. Salvicine has antimetastatic activity and shed new light on the complex roles of ROS and downstream signaling molecules, particularly p38 MAPK, in the regulation of integrin function and cell adhesion. | |
| BCN3224 | Voacangine |
| 1. Voacangine is a novel transient receptor potential vanilloid type 1 (TRPV1) antagonist. 2. Voacangine shows mod. cytotoxic activity, also some CNS, brachycardial and hypotensive action. 3. Voacangine significantly suppresses in vitro angiogenesis, such as VEGF-induced tube formation and chemoinvasion. 4. Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50, 9 μM), but it shows noncompetitive inhibition against icilin (IC50, 7 μM), it may contribute to the development of a novel class of stimulus-selective TRPM8 blockers. | |
| BCN3263 | Chebulinic acid |
| Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity; it also is a natural inhibitor of vascular endothelial growth factor-A mediated angiogenesis. Chebulinic acid has hypotensive, antioxidant, anti-HIV, and anti-ulcer activities. Chebulinic acid has inhibitory effect on erythroid differentiation likely through changing transcriptional activation of differentiation relative genes, it or other tannins might influence the efficiency of some anti-tumor drugs-induced differentiation or the hematopoiesis processes. | |
| BCN3418 | (-)-Lariciresinol |
| 1. Lariciresinol administration can inhibit the tumor growth and tumor angiogenesis, conceivable importance of dietary lignan lariciresinol in inhibition of breast cancer development. | |
| BCN3477 | Purpurin |
| Purpurin is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. Purpurin is a novel specific inhibitor of Adipocyte-derived leucine aminopeptidase, it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. | |
