Products with Antiangiogenic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6240 | Dammarenediol II |
| 1. Dammarenediol II synthase is a key rate-limiting enzyme during the process of rice synthesizes dammarane-type ginsenosides. 2. Dammarenediol II can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber formation and vascular endothelial-cadherin disruption, suggests that the natural drug dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy. 3. The medicinally important dammarenediol II can be ectopically produced in tobacco, and the production of dammarenediol-II in tobacco plants allows them to adopt a viral defense system. | |
| BCN6247 | 3-O-(E)-p-Coumaroylbetulin |
| 1. 3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM. | |
| BCN6250 | Hispidulin |
| Hispidulin has anti-oxidative, anti-inflammatory, anti-cancer, antiepileptic, neuroprotective, anti-osteoporotic and bone resorption attenuating effects, it targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1. | |
| BCN6265 | Sinomenine |
| Sinomenine shows neuroprotective, anti- rheumatoid arthritis, anti-inflammatory and immunosuppressive effects, it can attenuate 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice and the therapeutic mechanism may be related to the reduction of up-regulated colonic TNF-alpha and IFN-gamma production caused by TNBS. Sinomenine also provides a novel therapy to treat ICH induced brain injury. Sinomenine can prevent galactosamine (GalN)/lipopolysaccharide (LPS) -treated hepatic failure by suppressing TNF production and/or reactive oxygen generation. | |
| BCN6266 | Sodium Aescinate |
| 1. Sodium aescinate has anti-inflammatory and antioxidant activities, may effectively control and improve wound healing in diabetic rats. 2. Sodium aescinate can protect the lung injury induced by intestinal ischemia/reperfusion (I/R), which may be mediated by inhibiting lipid peroxidation, upregulating Bcl-2 gene protein expression, improving the ratio of Bcl-2/ Bax to inhibit lung apoptosis. 3. Sodium aescinate has obvious antiangiogenic effect, the initiation of angiogenesis and proliferation of endothelial cell are inhibited and the secretion of VEGF is also decreased. 4. Sodium aescinate has immunity enhancing and antioxidative effects, sodium aescinate injection liquid can decrease oxidative injury and enhance immunity functions in hepatocellular carcinoma (HCC) mice. 5. Sodium aescinate can protect against liver injury induced by methyl parathion and that the mechanism of action is related to its antioxidative and anti-inflammatory effects. | |
