Products with Antibacterial bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5228 | gamma-Mangostin |
| gamma-Mangostin is a dual agonist that activates both PPARδ and PPARα, is also a novel competitive antagonist for the 5-HT2A receptors in vascular smooth muscles and platelets.gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells, and exhibits antihypertensive, anti-inflammatory, analgesic effects. gamma-Mangostin could as a preventive agent of the metabolic syndrome, and could serve as a micronutrient for colon cancer prevention. | |
| BCN5261 | Pachypodol |
| 1. Pachypodol has cytotoxic potential ,can inhibit the growth of CaCo 2 colon cancer cell line in vitro. 2. Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata. 3. Pachypodol exhibits anti-emetic effects. 4. Pachypodol inhibits the water-splitting enzyme activity. | |
| BCN5266 | Alpinumisoflavone |
| 1. Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation. 2. Alpinumisoflavone is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. 3. Alpinumisoflavone induces cell death, may be via repressing both the ERK/MAPK and NF-κB pathways. 4. Alpinumisoflavone, abyssione-V 4'-O-methyl ether, 6,8-diprenylgenistein, and burttinone are active against both Gram-negative and Gram-positive bacteria, the minimum inhibitory concentration values obtained (MIC) ranged from 3.9 ug/mL to 125 ug/mL. | |
| BCN5276 | Isoapetalic acid |
| 1. Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli.). | |
| BCN5280 | Nortrachelogenin |
| 1. (+)-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits. 2. (-)-Nortrachelogenin can induce membrane disruption and caspase-dependent apoptosis. 3. Nortrachelogenin shows anti-plasmodium activity of 14.50 dg/ml. 4. Nortrachelogenin has anti-inflammatory properties. 5. Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure. 6. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane. 7. (+)-Nortrachelogenin is moderately active against HIV-1 in vitro. 8. Nortrachelogenin shows moderate inhibiting activities on NF- κB signaling pathway induced by TNFα , with the IC50 value of 49.4 uM. | |
