Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5228 | gamma-Mangostin |
| gamma-Mangostin is a dual agonist that activates both PPARδ and PPARα, is also a novel competitive antagonist for the 5-HT2A receptors in vascular smooth muscles and platelets.gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells, and exhibits antihypertensive, anti-inflammatory, analgesic effects. gamma-Mangostin could as a preventive agent of the metabolic syndrome, and could serve as a micronutrient for colon cancer prevention. | |
| BCN5243 | Myricanone |
| 1. Myricanone has anticancer activity. 2. Myricanone has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-κB and STAT3 signalling cascades. 3. Myricanone displays significant antioxidant activity. 4. Myricanone shows in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. | |
| BCN5245 | Kaempferol 3-neohesperidoside |
| 1. Kaempferol 3-neohesperidoside has insulin-like properties in terms of glucose lowering. 2. Kaempferol 3-neohesperidoside stimulates glucose uptake in the rat soleus muscle via the PI3K and PKC pathways and, at least in part, independently of MEK pathways and the synthesis of new glucose transporters. 3. Kaempferol 3-neohesperidoside possesses not only a significant anticancer effect against HepG2 cells, but also an effective and a dose dependent hepatoprotective and antioxidant activities due to the presence of flavonoids content. | |
| BCN5257 | Quercetin 3,4'-dimethyl ether |
| 1. Quercetin 3,4’-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM). 2. 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone (Quercetin 3,4’-dimethyl ether ) has high cytotoxic against leukemia cells, it induces cell death is mediated by an intrinsic dependent apoptotic event involving mitochondria and MAPKs, and through a mechanism independent of the generation of reactive oxygen species, suggests that it could be useful in the development of novel anticancer agents. 3. Quercetin 3,4’-dimethyl ether shows anti-inflammatory activity. | |
| BCN5259 | Hypophyllanthin |
| 1. Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. 2. Hypophyllanthin can modulate the vascular tension via the endothelium-independent mechanisms. 3. Hypophyllanthin can directly inhibit P-gp activity and does not interfere with MRP2 activity, it may reversibly inhibit P-gp function. 4. Hypophyllanthin offers a promising means for treatment of chronic muscle pain. 5. Hypophyllanthin has estrogenic properties against carbofuran induced toxicity in female rats. | |
