Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4966 | Patchouli alcohol |
| Patchouli alcohol has anti-inflammatory, neuroprotective, anti-cancer, anti-oxidant, gastroprotective, immunomodulatory, and antibacterial effects, which may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-α, IL-1β, IL-6, iNOS and COX-2. Patchouli alcohol significantly accelerates the recovery of the UV-induced skin lesions, evidently through anti-oxidant and anti-inflammatory action, as well as down-regulation of the MMP-1 and MMP-3 expression. | |
| BCN4977 | Dauricine |
| Dauricine may has neuroprotective, and anti-tumor effects, it can pass the blood‑brain barrier, and that P‑glycoprotein has an important role in the transportation of Dauricine across the blood‑brain barrier, it can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. Dauricine also has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. | |
| BCN4981 | Germacrone |
| Germacrone has anti-tumor activity, it can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung. Germacrone also moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM, and produces two oxidized metabolites and four glutathione conjugates. | |
| BCN4982 | Platycodin D |
| Platycodon D shows antinociceptive, and anti-inflammatory activities, it can induce autophagy in NCI-H460 and A549 cells through inhibiting PI3K/Akt/mTOR signaling pathway and activating JNK and p38 MAPK signaling pathways. Platycodon D can inhibit migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Platycodin D is also a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen. | |
| BCN4990 | Praeruptorin D |
| 1. Praeruptorin D exhibits antitumor and anti-inflammatory activities. 2. Praeruptorin D and E protect mice from hydrochloric acid (HCl)-induced lung injury by inhibiting PMNs influx, IL-6 release and protein exudation. 3. Praeruptorin D can significantly up-regulate CYP3A4 expression and activity via the Pregnane X receptor (PXR)-mediated pathway. | |
