Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4732 | Narciclasine |
| 1. Narciclasine displays marked proapoptotic and cytotoxic activity, as does pancratistatin, and significant in vivo anticancer effects in various experimental models, but it is also associated with severe toxic side effects. 2. Narciclasine acts on the auxin signaling pathway upstream of TIR1, which modulates Aux/IAA protein degradation, and thereby affects the auxin-mediated responses in Arabidopsis roots, inhibits the root hair development of lettuce seedlings. 3. The alkaloid Narciclasine is the bioactive compound responsible for the anti-inflammatory action of HCE. | |
| BCN4734 | Annonacin |
| 1. Annonacin is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons; can cause significant cell death in various cancer cell lines.. 2. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. 3. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases. | |
| BCN4742 | Tephrosin |
| 1. Tephrosin may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), DG is currently under clinical evaluation for targeting tumor cells. 2. Tephrosin has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2. 3. Tephrosin could exert antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells. | |
| BCN4750 | 5-Heptadecylresorcinol |
| 1. 5-Heptadecylresorcinol has strong inhibitory property against the growth of PC3 cells. | |
| BCN4774 | Enniatin B |
| 1. Enniatin B can decrease Monocytes' endocytosis ability and an increase of CD71. 2. Enniatin B has anticancer benefits, especially for the treatment of cervical cancer. 3. Enniatin B has extensive hepatic metabolism, that reduces in vivo potential . 4. Enniatin B has antiangiogenic properties, indicated by a strong inhibition of human endothelial cell migration and tube formation. | |
