Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5020 | Vitexicarpin |
| Vitexicarpin has shown antitumor, cytotoxicity, anti-inflammatory, analgesic and immunoregulatory properties.Vitexicarpin can act as a novel angiogenesis inhibitor, it exerts good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor-(VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner. It can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. | |
| BCN5022 | Fargesin |
| Fargesin has anti-inflammatory, anti-cancer, antihypertensive , and anti-bone-resorbing effects, it is widely used in the treatment of managing rhinitis, inflammation, histamine, sinusitis, and headache. Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice by activating Akt and AMPK in WAT. It as a potential β1 adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. | |
| BCN5037 | 4-Methoxycinnamic acid |
| 4-Methoxycinnamic acid is a photosensitive compound, it shows various pharmacologic actions such as anti-cancer, hepatoprotective and antihyperglycemic activities, it also can stimulate insulin secretion from pancreatic β-cells by increasing Ca2+ influx via the L-type Ca2+ channels, but not through the closure of ATP-sensitive K+ channels. 4-Methoxycinnamic acid can strongly inhibit the diphenolase activity of mushroom tyrosinase, with the IC 50 value of 0.42 mM, and the inhibition is reversible. | |
| BCN5039 | 2-Hydroxycinnamic acid |
| 2-Hydroxycinnamic acid has photooxidant activity; 2-hydroxycinnamic acid germanium has strong inhibitory effect on the tumor U14; trans-2-hydroxycinnamic acid has efficacy against trichlorfon-induced oxidative stress in wistar rats. | |
| BCN5049 | Cytochalasin D |
| 1. Cytochalasin D-induced extension of neurite-like processes might correlate with enhanced accumulation of PrPres. 2. Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. 3. Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis. 4. Cytochalasin D stimulates the expression of TF in B16 melanoma cells, activating both coagulation-dependent and -independent pathways via binding to FVIIa, eventually promoting lung metastasis. 5. Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus. 6. Cytochalasin D is an inhibitor of microfilament-dependent phagocytosis, it (0.5 or 1.0 micrograms/ml) can inhibit intracellular multiplication of L. pneumophila in U937 monocytes. 7. Cytochalasin D may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. | |
