Products with Anticonvulsant bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4974 | Isopulegol |
| Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant properties. | |
| BCN4978 | Strychnine |
| Strychnine-insensitive glycine site NMDA antagonist ( R )-HA-966 have neuroprotective effects in an experimental model of Parkinson's disease. Strychnine insensitive glycine receptor has anticonvulsant properties.Strychnine can block binaural inhibition in lateral superior olivary neurons, decrease the voltage-dependent Ca2+ current of both Aplysia and frog ganglion neurons. Strychnine also has inhibitory effects on GABA- and glycine-induced responses. | |
| BCN4979 | Rhynchophylline |
| Rhynchophylline, a noncompetitive antagonist of the NMDA receptor, which has anti-inflammatory, anti-hypertension, cardiacprotective and neuroprotective activities. Rhynchophylline can markedly inhibit rabbit platelet aggregation induced by ADP or thrombin possibly by depressing the inflow of Ca2+ and the rise of the cytoplasmic free calcium level in platelet.Rhynchophylline can reduce the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) significantly, decrease plasma Ang II, ADMA, and AT1R levels, and promote serum NO and NOS levels, which has the protection of vascular endothelial function. | |
| BCN5156 | Oxysophocarpine |
| Oxysophocarpine shows anti-inflammatory, neuroprotective, anticonvulsant, and anti-nociceptive effects, it also attenuates inflammatory pain by suppressing the levels of phosphorylation of extracellular signal-regulated kinase 1/2, cyclooxygenase-2, prostaglandin E2, tumor necrosis factor α, interleukin-1 beta and interleukin-6. | |
| BCN5205 | Xanthotoxin |
| Xanthotoxin (Methoxsalen ) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Xanthotoxin has anticonvulsant activities, it can protect the animals against maximal electroshock-induced seizures; Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis, it may be considered to be a new therapeutic candidate for treating osteoporosis. | |
