Products with Antifibrotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2648 | Tetrahydroberberine |
| Tetrahydroberberine, with D(2) receptor antagonist and 5-HT(1A) receptor agonist properties, has significant potential as a therapeutic for treatment of FD; it has antidopaminergic effect, and other pharmacological action on the central nervous system. Tetrahydroberberine can inhibit the rabbit platelet aggregation. | |
| BCN3327 | Didymin |
| Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture, it induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Didymin possesses antioxidant, anti-inflammation and anti-cancer properties. | |
| BCN4214 | Ethyl caffeate |
| Ethyl caffeate is a potent chemopreventive compound against skin carcinogenesis caused by solar UV exposure, it strongly inhibits neoplastic transformation of JB6 Cl41 cells without toxicity. PI3K, ERK1/2, and p38 kinase activities were suppressed by direct binding with HOEC in vitro. Ethyl caffeate also has anti-inflammatory, hepatprotective activities. | |
| BCN4304 | Kaerophyllin |
| 1. Kaerophyllin can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, possibly through upregulation of PPAR-γ expression. 2. Kaerophyllin inhibits AB-induced LX-2 activation and migration with downregulation of Akt/ERK phosphorylations and NF-κB activity. | |
| BCN4992 | Peimisine |
| Peimisine may have antihypertensive action, it can inhibit angiotensin I converting enzyme activity in a dose-dependent manner(the IC50 value of 526.5 microM). Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. It plays a protective role against LPS-induced acute lung injury, and against the experimental hepatic fibrosis formation. | |
