Products with Antifibrotic Bioactivity

Explore BioCrick products associated with Antifibrotic biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN2648	Tetrahydroberberine
Tetrahydroberberine, with D(2) receptor antagonist and 5-HT(1A) receptor agonist properties, has significant potential as a therapeutic for treatment of FD; it has antidopaminergic effect, and other pharmacological action on the central nervous system. Tetrahydroberberine can inhibit the rabbit platelet aggregation.
BCN3327	Didymin
Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture, it induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Didymin possesses antioxidant, anti-inflammation and anti-cancer properties.
BCN4214	Ethyl caffeate
Ethyl caffeate is a potent chemopreventive compound against skin carcinogenesis caused by solar UV exposure, it strongly inhibits neoplastic transformation of JB6 Cl41 cells without toxicity. PI3K, ERK1/2, and p38 kinase activities were suppressed by direct binding with HOEC in vitro. Ethyl caffeate also has anti-inflammatory, hepatprotective activities.
BCN4304	Kaerophyllin
1. Kaerophyllin can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, possibly through upregulation of PPAR-γ expression. 2. Kaerophyllin inhibits AB-induced LX-2 activation and migration with downregulation of Akt/ERK phosphorylations and NF-κB activity.
BCN4992	Peimisine
Peimisine may have antihypertensive action, it can inhibit angiotensin I converting enzyme activity in a dose-dependent manner(the IC50 value of 526.5 microM). Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. It plays a protective role against LPS-induced acute lung injury, and against the experimental hepatic fibrosis formation.

Antifibrotic Bioactivity Products