Products with Antihyperglycemic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4303 | Obacunone |
| Obacunone is a novel activator of Nrf2, which exhibits anti-cancer, anti-inflammatory, antivirulence, insecticidal, anti-proliferative and anti-aromatase activities. Obacunone stimulates muscle hypertrophy and prevents obesity and hyperglycemia, and that these beneficial effects are likely to be mediated through the activation of TGR5 and inhibition of PPARγ transcriptional activity. Obacunone significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM, and it also inhibits the p38 MAPK signaling pathway. | |
| BCN4376 | Stigmasterol |
| Stigmasterol is used as a precursor in the manufacture of synthetic progesterone, it is an antagonist of the bile acid nuclear receptor FXR, which has anti-inflammatory, thyroid inhibitory, cholesterol-lowering, antiperoxidative and hypoglycemic effects; it has indicated that stigmasterol may be useful in prevention of certain cancers, including ovarian, prostate, breast, and colon cancers. Stigmasterol inhibits the NF-kappaB pathway. | |
| BCN4410 | alpha-Amyrin acetate |
| 1. Alpha-Amyrin acetate has anti-inflammatory activity. 2. Alpha-Amyrin acetate has antispasmodic profile and the relaxant effects. 3. Alpha-Amyrin acetate can decrease blood engorgement time and feeding rate and decline fecundity which reduce the overall survival and reproductive capacity of the malaria vector A. stephensi. 4. The oral administration of alpha-Amyrin acetate can significantly improve the diabetic condition in streptozotocin-induced diabetic rats and in diabetic db/db mice at 50 mg kg(-1) dose level. | |
| BCN4470 | Scopoletin |
| Scopoletin exhibits antifungal, anti-allergic, anti-aging, and hypouricemic activities, it exerts anti-RA action probably through suppressing IL-6 production from fibroblast-like synoviocytes via MAPK/PKC/CREB pathways. Scopoletin can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet. | |
| BCN4477 | Umbelliferone |
| Umbelliferone is a competitive inhibitor of alkaline phosphatase. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with antinociceptive, anti-inflammatory, anti-hyperglycaemic, anti-allergic, molluscicidal and anti-tumor activities. Umbelliferone has stimulatory effect on adipocyte differentiation likely occurs through up-regulation of adipogenic transcription factors and downstream adipocyte-specific gene expression. | |
