Products with Antihyperglycemic Bioactivity

Explore BioCrick products associated with Antihyperglycemic biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN2280	Saponarin
1. Saponarin, which isolated from Gypsophila trichotoma Wend, shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. 2. Saponarin has antioxidant activity against cocaine-induced oxidative stress and hepatotoxicity. 3. Saponarin exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling. 4. Saponarin shows hypoglycemic activity in the range of 20-80 mg/kg compared to 100-200 mg/kg for acarbose as reported. 5. Saponarin is characterized as α-glucosidase inhibitor present in Tinospora cordifolia, it also has hypoglycemic activity. 6. Saponarin exerts slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR), however, such effect is not observed in streptozotocin-induced diabetic SHR (SHR-D), indicates that diabetes and hypertension in combination are more difficult to be modulated by saponarin.
BCN2332	Forskolin
Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin has antitumor, antioxidant and antiinflammatory actions, it may cause genotoxic effects. Chronic administration of Forskolin can decrease fasting blood glucose levels, it is effective in preventing diet induced obesity.
BCN2371	Trigonelline
Trigonelline (1-methylpyridinium-3-carboxylate), an alkaloid present in coffee and fenugreek seed, exhibits phytoestrogenic, anti-adipogenesis, and anticancer activities, it also can reduce early glucose and insulin responses. Trigonelline has inhibition of the Nrf2 transcription factor and PPAR-γ.
BCN2384	3,4,5-Tricaffeoylquinic acid
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease. 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways, the effect be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH.
BCN2402	Geraniin
Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, has anti-oxidant , and anti-hyperglycemic activities, with an IC50 of 43 μM. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Geraniin induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death.

Antihyperglycemic Bioactivity Products