Products with Antihyperglycemic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1359 | 6alpha-Hydroxycleroda-3,13-dien-16,15-olid-18-oic acid |
| 1. (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid is one alpha- glucosidase inhibitory constituent from Duranta repens. | |
| BCN1388 | 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene |
| 1.1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities. 2.1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has hypoglycemic activity. | |
| BCN1789 | Benzylamine |
| 1. Benzylamine has antihyperglycemic effect, observed during glucose tolerance test in control. | |
| BCN2235 | Estriol |
| Estriol (E3), an endogenous estrogen predominantly produced during human pregnancy, is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. E3 can blunt the postprandial glycemic surge in rats through modulating the level of intestinal glucose transporters. E3 exerts a mitogenic effect on T-47D and MCF-7 cells at concentrations of 10(-9)M (288 pg/ml) and higher. | |
| BCN2280 | Saponarin |
| 1. Saponarin, which isolated from Gypsophila trichotoma Wend, shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. 2. Saponarin has antioxidant activity against cocaine-induced oxidative stress and hepatotoxicity. 3. Saponarin exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling. 4. Saponarin shows hypoglycemic activity in the range of 20-80 mg/kg compared to 100-200 mg/kg for acarbose as reported. 5. Saponarin is characterized as α-glucosidase inhibitor present in Tinospora cordifolia, it also has hypoglycemic activity. 6. Saponarin exerts slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR), however, such effect is not observed in streptozotocin-induced diabetic SHR (SHR-D), indicates that diabetes and hypertension in combination are more difficult to be modulated by saponarin. | |
