1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dieneCAS# 63644-68-8 |
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| Cas No. | 63644-68-8 | SDF | Download SDF |
| PubChem ID | 12362488 | Appearance | Powder |
| Formula | C19H20O4 | M.Wt | 312.4 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(1E,4E)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dienyl]-2-methoxyphenol | ||
| SMILES | COC1=C(C=CC(=C1)C=CCC=CC2=CC(=C(C=C2)O)OC)O | ||
| Standard InChIKey | NUITXMZDWYBZLK-YDFGWWAZSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The rhizomes of Curcuma longa L.
| Description | 1.1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities. 2.1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has hypoglycemic activity. |
| Targets | PARP |
1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene Dilution Calculator
1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.201 mL | 16.0051 mL | 32.0102 mL | 64.0205 mL | 80.0256 mL |
| 5 mM | 0.6402 mL | 3.201 mL | 6.402 mL | 12.8041 mL | 16.0051 mL |
| 10 mM | 0.3201 mL | 1.6005 mL | 3.201 mL | 6.402 mL | 8.0026 mL |
| 50 mM | 0.064 mL | 0.3201 mL | 0.6402 mL | 1.2804 mL | 1.6005 mL |
| 100 mM | 0.032 mL | 0.1601 mL | 0.3201 mL | 0.6402 mL | 0.8003 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.[Pubmed:25068729]
J Enzyme Inhib Med Chem. 2015 Jun;30(3):383-8.
Aminomethyl derivatives of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities. The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC and HPLF non-malignant cells, which reveals the tumour-selectivity of these aminomethyl derivatives, Mannich bases. Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities.
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