Pramoxine HClCAS# 637-58-1 |
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Quality Control & MSDS
3D structure
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| Cas No. | 637-58-1 | SDF | Download SDF |
| PubChem ID | 73957 | Appearance | Powder |
| Formula | C17H28ClNO3 | M.Wt | 329.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Pramoxine hydrochloride | ||
| Solubility | DMSO : 100 mg/mL (303.16 mM; Need ultrasonic) H2O : 100 mg/mL (303.16 mM; Need ultrasonic) | ||
| Chemical Name | 4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride | ||
| SMILES | [H+].[Cl-].CCCCOc1ccc(OCCCN2CCOCC2)cc1 | ||
| Standard InChIKey | SYCBXBCPLUFJID-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Pramocaine hydrochloride is a topical anesthetic, and used as an antipruritic. |
Pramoxine HCl Dilution Calculator
Pramoxine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0316 mL | 15.1579 mL | 30.3159 mL | 60.6318 mL | 75.7897 mL |
| 5 mM | 0.6063 mL | 3.0316 mL | 6.0632 mL | 12.1264 mL | 15.1579 mL |
| 10 mM | 0.3032 mL | 1.5158 mL | 3.0316 mL | 6.0632 mL | 7.579 mL |
| 50 mM | 0.0606 mL | 0.3032 mL | 0.6063 mL | 1.2126 mL | 1.5158 mL |
| 100 mM | 0.0303 mL | 0.1516 mL | 0.3032 mL | 0.6063 mL | 0.7579 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.
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Ion-Selective Electrodes for the Potentiometric Determination of Pramoxine HCl Using Different Ionophores.[Pubmed:24061370]
Acta Chim Slov. 2012 Dec;59(4):870-8.
Four novel Pramoxine HCl (PAM) selective electrodes were investigated with 2-nitrophenyl octylether as a plasticiser in a polymeric matrix of polyvinyl chloride (PVC). Sensor 1 was fabricated using sodium-tetraphenylborate (TPB) as an anionic exchanger without incorporation of an ionophore. Sensor 2 used 2-hydroxy propyl -cyclodextrin as an ionophore, while sensors 3 and 4 were constructed using 4-sulfocalix-6-arene and 4-sulfocalix-8-arene respectively as ionophores. Linear responses of PAM within the concentration ranges of 1.0 x 10-4 to 1.0 x 10-2 mol L-1 and 1.0 x 10-5 to 1.0 x 10-2 mol L-1 were obtained using sensors 1 and 2, respectively and 1.0 x 10-6 to 1.0 x 10-2 mol L-1 were obtained using sensors 3 and 4. Nernstian slopes of 50.4 +/- 0.6, 54.3 +/- 0.8, 56.3 +/- 0.3 and 59.1 +/- 0.5 mV/decade over the pH range of 3.0-6.0 were observed. The selectivity coefficients of the developed sensors indicated excellent selectivity for PAM. The utility of 2-hydroxy- propylcyclodextrin (2HP-beta-CD) and 4-sulfocalix [6,8] arene (SC 6, 8) as ionophores had a significant influence on increasing the membrane sensitivity and selectivity of sensors 2, 3 and 4 compared to sensor 1. The proposed sensors displayed useful analytical characteristics for the determination of PAM in bulk powder, pharmaceutical formulation, and in biological fluid. Validation of the method showed the suitability of the proposed electrodes for the use in the quality control assessment of the drug. Furthermore, statistical comparison between the results obtained by the proposed method and the official method of the drug was performed and no significant difference was found.
