Products with Antimicrobial bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3176 | Mahanine |
| 1. Mahanine has a dose- and time-dependent anti-proliferative activity in acute lymphoid (MOLT-3) and chronic myeloid (K562) leukemic cell lines. 2. Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. 3. Mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, is an encouraging therapeutic choice for advanced prostatic cancer. 4. Mahanine inhibited growth of PC3 and LNCaP prostate cancer cells in a dose and time-dependent manner, inhibits growth and induces apoptosis in both androgen-responsive, LNCaP and androgen-independent, PC3 cells by targeting cell survival pathway. | |
| BCN3256 | Licoflavone C |
| 1. Licoflavone C has cytotoxic effect . 2. Licoflavone C has antioxidative effect. 3. Licoflavone C has protective effect toward the chromosome damage induced by DAU or MMC in cultured human peripheral lymphocytes. 4. Licoflavone C exhibits a dose-dependent antagonistic activity at concentrations up to 10−4 M, but stimulates β-galactosidase expression at higher concentrations resulting in a U-shaped-like dose-response curve. | |
| BCN3797 | Limonene |
| Limonene has antioxidant activity, it at all concentrations reveal a reduction in the frequency of MN and DNA damage induced by H2O2. | |
| BCN3906 | 10-Hydroxycanthin-6-one |
| 1. 10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 2. 10-Hydroxycanthin-6-one has in vitro antimalarial activity. 3. 10-Hydroxycanthin-6-one has cytotoxic activity, it could be a plant anticancer agent. | |
| BCN4225 | Catalposide |
| 1. Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. 2. Catalposide is a potent inducer of HO-1 and HO-1 induction is responsible for the catalposide-mediated cytoprotection against oxidative damage. 3. Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-α, is hypolipidemic by activation of PPARαvia a ligand-mediated mechanism that modulates the expression of in lipid metabolism genes in hepatocytes. 4. Catalposide can attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of trinitrobenzene sulfonic acid-induced colitis in mice, it may be an effective agent for the treatment of diseases characterized by mucosal inflammation. | |
