Products with Hepatoprotective Bioactivity

Explore BioCrick products associated with Hepatoprotective biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN2271	Gomisin N
Gomisin N has anti-oxdiant, anti-inflammatory, anti-cancer and anti-hepatitis activities; it produces beneficial sedative and hypnotic bioactivity, which may be mediated by the modification of the serotonergic and GABAergic system. Gomisin N can enhance TNF-α-induced apoptosis by suppressing of NF-κB and EGFR signaling pathways, and potentiate TRAIL-induced apoptosis through ROS-mediated up-regulation of death receptors 4 and 5.
BCN2280	Saponarin
1. Saponarin, which isolated from Gypsophila trichotoma Wend, shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. 2. Saponarin has antioxidant activity against cocaine-induced oxidative stress and hepatotoxicity. 3. Saponarin exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling. 4. Saponarin shows hypoglycemic activity in the range of 20-80 mg/kg compared to 100-200 mg/kg for acarbose as reported. 5. Saponarin is characterized as α-glucosidase inhibitor present in Tinospora cordifolia, it also has hypoglycemic activity. 6. Saponarin exerts slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR), however, such effect is not observed in streptozotocin-induced diabetic SHR (SHR-D), indicates that diabetes and hypertension in combination are more difficult to be modulated by saponarin.
BCN2295	Desmethoxy yangonin
Desmethoxyyangonin is a reversible inhibitor of MAO-B, it may have important therapeutic value for treatment of neurodegenerative disorders and Parkinson's Disease. Desmethoxy yangonin protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways.
BCN2299	Sauchinone
Sauchinone possesses diverse pharmacological properties, such as hepatoprotective, neuroprotective, anti-inflammatory and anti-tumor effects. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Sauchinone can be used for the prevention of functional β-cell damage, it prevents cytokine-induced NO production, iNOS expression,JAK/STAT activation,and NF-κB activation and inhibition of glucose-stimulated insulin secretion (GSIS).
BCN2319	Ginkgetin
Ginkgetin is a good STAT3 inhibitor , which has anti-inflammatory, neuroprotective, anti-influenza virus and anti-fungal activities. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment.

Hepatoprotective Bioactivity Products