Products with Smooth muscle relaxing activity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1665 | Marmin |
| 1. Marmin can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels. 2. Marmin, skimmianine, aegeline, aurapten, zeorin, and dustanin are potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor. 3. S-trans-Marmin shows potent antibacterial, fungicidal, and algicidal properties. 4. Marmin shows a cell-growth inhibitory effect against L1210 and K562 in vitro. 5. Marmin and nobiletin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine. | |
| BCN2977 | Guaifenesin |
| Guaifenesin is also a centrally acting skeletal muscle relaxant. Guaifenesin has antitussive effects, it can inhibit the cough-reflex sensitivity in acute viral cough, it is an expectorant commonly by thinning the mucus or phlegm in the lungs. | |
| BCN4237 | Trifolirhizin |
| Trifolirhizin possesses potential anti-inflammatory and anti-cancer activities, it inhibits acetylcholine mediated airway smooth muscle (ASM) contraction or directly relaxes pre-contracted ASM independent of β 2 -adrenoceptors. Trifolirhizin may be a a candidate as skin-whitening agents, it exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis. | |
| BCN4909 | Gentiopicroside |
| Gentiopicroside has been developed into a novel traditional Chinese drug named gentiopicroside injection, and it was approved for the treatment of acute jaundice and chronic active hepatitis by SFDA.Gentiopicroside has analgesic, smooth muscle relaxing, antibacterial, and free radical scavenging activities, it exerts anti-inflammatory effects on experimental acute colitis through attenuating the expression levels of TNF-α, IL-1β, IL-6, iNOS and COX-2. | |
