Products with Smooth muscle relaxing activity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5006 | Scopolamine butylbromide |
| Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM, it possesses anticholinergic, and anti-tumor effects, it used as an abdominal-specific antispasmodic agent. Scopolamine butylbromide is effective in preventing succinylcholine-induced bradycardia in infants and children. | |
| BCN5049 | Cytochalasin D |
| 1. Cytochalasin D-induced extension of neurite-like processes might correlate with enhanced accumulation of PrPres. 2. Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. 3. Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis. 4. Cytochalasin D stimulates the expression of TF in B16 melanoma cells, activating both coagulation-dependent and -independent pathways via binding to FVIIa, eventually promoting lung metastasis. 5. Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus. 6. Cytochalasin D is an inhibitor of microfilament-dependent phagocytosis, it (0.5 or 1.0 micrograms/ml) can inhibit intracellular multiplication of L. pneumophila in U937 monocytes. 7. Cytochalasin D may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. | |
| BCN5097 | Thalictrimine |
| 1. Allocryptopine and protopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. 2. Allocryptopine induces a relaxing effect on the ileum by inhibiting phosphodiesterase enzyme, and thus elevating cellular cAMP and its contractile effect on the urinary bladder by affecting alpha-adrenergic receptors in this tissue. 3. Allocryptopine and benzyltetrahydropalmatine can block human ether-a-go-go related gene (hERG) potassium channels expressed in HEK293 cells. 4. Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis. | |
| BCN5268 | Pterosin Z |
| 1. Pterosin Z has smooth muscle relaxant activity, is approximately equipotent with that of the related fungal pterosin (EC50 of 2.9 +/- 1.6 x 10(-6) M). | |
| BCN5712 | Onitin |
| 1. Onitin shows super-oxide and DPPH free radical scavenging effects. 2. Onitin exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. | |
