Natural Products from Aconitum bulleyanum
Natural Products Isolated from Aconitum bulleyanum
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Natural Products from Aconitum bulleyanum
3 natural product s associated with Aconitum bulleyanum
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN2516 |
Crassicauline A
|
79592-91-9 | COA |
| BCN2504 |
Lannaconitine
|
32854-75-4 | COA |
| BCN6261 |
Yunaconitine
|
70578-24-4 | COA |
References
Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MS(n) combined with specific inhibitors.[Pubmed: 25425064]
Bulleyaconitine A (BLA) from Aconitum bulleyanum plants is usually used as anti-inflammatory drug in some Asian countries. It has a variety of bioactivities, and at the same time some toxicities. Since the bioactivities and toxicities of BLA are closely related to its metabolism, the metabolites and the metabolic pathways of BLA in rat liver microsomes were investigated by HPLC-MS(n). In this research, the 12 metabolites of BLA were identified according to the results of HPLC-MS(n) data and the relevant literature. The results showed that there are multiple metabolites of BLA in rat liver microsomes, including demethylation, deacetylation, dehydrogenation deacetylation and hydroxylation. The major metabolic pathways of BLA in rat liver microsomes were clarified by HPLC-MS combined with specific inhibitors of CYP450 isoforms. As a result, CYP3A and 2C were found to be the principal CYP isoforms contributing to the metabolism of BLA. Moreover, CYP2D6 and 2E1 are also more important CYP isoforms for the metabolism of BLA. While CYP1A2 only affected the formation rate of M11, its effect on the metabolism of BLA is very small.
[Chemical constituents of Aconitum bulleyanum].[Pubmed: 24380280]
To study the chemical constituents of chloroform fraction from Aconitum bulleyanum.
Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo.[Pubmed: 17585219]
Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plants. BLA has been approved for the treatment of chronic pain and rheumatoid arthritis in China, but its underlying mechanism remains unclear.
Two norditerpenoid ester alkaloids from Aconitum bulleyanum.[Pubmed: 12494351]
Two new norditerpenoid alkaloids, 8-acetyl-14-p-methoxybenzoate of talatisamine (1) and 14-p-methoxybenzoate of talatisamine (2), were isolated from Aconitum bulleyanum Diels. The structures were elucidated on the basis of spectroscopic and chemical studies.
[Diterpenoid alkaloids from Aconitum bulleyanum Diels].[Pubmed: 11599346]
To investigate the diterpenoid alkaloids from Aconitum bulleyanum.