Natural Products from Euphorbia ebracteolata
Natural Products Isolated from Euphorbia ebracteolata
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Natural Products from Euphorbia ebracteolata
1 natural product associated with Euphorbia ebracteolata
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN2973 |
1-Octacosanol
|
557-61-9 | COA |
References
Abietane Diterpernoids from the Roots of Euphorbia ebracteolata.[Pubmed: 29557523]
A new ent-abietane diterpernoid, named ebracteolata D (1), along with 11 known analogues, was isolated from the roots of Euphorbia ebracteolata Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis and molecular modeling. Cytotoxicity of compounds 1-12 was evaluated as well as the effect on the NF-κB pathway. Among them, compound 12, jolkinolide B, displayed broad inhibitory effects against proliferation of tumor cell lines. Mechanistic studies indicated that the compound 12 can inhibit TNF-α induced NF-κB activation, thereby inducing tumor cell apoptosis.
Diterpenoids from the roots of Euphorbia ebracteolata and their anti-tuberculosis effects.[Pubmed: 29453078]
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Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2.[Pubmed: 29253734]
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Four new compounds from the roots of Euphorbia ebracteolata and their inhibitory effect on LPS-induced NO production.[Pubmed: 29221703]
Three new diterpenoids, ebractenoids O~Q (1-3), and a new phenolic glucoside, γ-pyrone-3-O-β-d-(6-galloyl)-glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated. All of them exhibited significant inhibitory activity.
Heterodimeric Diterpenoids Isolated from Euphorbia ebracteolata Roots and Their Inhibitory Effects on α-Glucosidase.[Pubmed: 29148766]
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[Phenolic acid derivatives of Euphorbia ebracteolata].[Pubmed: 29139269]
A variety of chromatographic methods were applied to research the chemical composition of the roots of Euphorbia ebracteolata. Meanwhile, the structures of these compounds were identified by spectroscopic data, such as 1D, 2D NMR and HR-ESI-MS. In the present research, a new phenolic acid compound, 1,3,4,5-tetrahydroxy-2-O-β-D-[(6'-Gallic acyl)-glucopyranyl] isopentane(1), was isolated from the roots of E. ebracteolata, as well as three known compounds, isopropyl-2-O-β-D-(6'-gallic acyl)-glucopyranoside(2), ellagic acid(3) and 3,4'-di-O-methylellagic acid(4) respectively. Additionally, compounds 2 and 4 were isolated from the Euphorbia genus for the first time.
Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A.[Pubmed: 29109538]
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Antioxidant acetophenone glycosides from the roots of Euphorbia ebracteolata Hayata.[Pubmed: 28856938]
A new acetophenone diglycoside, 2,4-dihydroxy-6-methoxy-3-methyl-acetophenone 4-O-gentiobioside (1), along with six know analogues (2-6), were isolated from the roots of Euphorbia ebracteolata. The structures of these isolates were determined by UV, HRESIMS, 1D and 2D NMR spectral analyses. In addition, all acetophenones showed moderate DPPH free radical scavenging capability, and no cytotoxicity against five human cancer cell lines.
Phenolic glycosides and monoterpenoids from the roots of Euphorbia ebracteolata and their bioactivities.[Pubmed: 28760607]
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