1-Octacosanol

CAS# 557-61-9

1-Octacosanol

Catalog No. BCN2973----Order now to get a substantial discount!

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Quality Control of 1-Octacosanol

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Chemical structure

1-Octacosanol

3D structure

Chemical Properties of 1-Octacosanol

Cas No. 557-61-9 SDF Download SDF
PubChem ID 68406 Appearance Oil
Formula C28H58O M.Wt 410.76
Type of Compound Miscellaneous Storage Desiccate at -20°C
Synonyms n-Octacosanol, Octacosyl alcohol, Octanosol, Montanyl alcohol, Cluytyl alcoho
Solubility DMSO : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble)
*1-Octacosanol is usually formulated as a suspension.
Chemical Name octacosan-1-ol
SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCCO
Standard InChIKey CNNRPFQICPFDPO-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1-Octacosanol

The herbs of Triticum aestivum L.

Biological Activity of 1-Octacosanol

Description1-Octacosanol is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties, it is used as a nutritional supplement.
TargetsAntifection
In vitro

Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and Its Major Constituents.[Pubmed: 27051475]

Oxid Med Cell Longev. 2016;2016:1404505.

Oregano is a perennial shrub that grows in the mountains of the Mediterranean and Euro/Irano-Siberian regions.
METHODS AND RESULTS:
This study was conducted to identify the major constituents of the ethanolic Origanum vulgare extract and examine the cytotoxic, antioxidant, and antibacterial properties of the extract but more importantly the contribution of its specific major constituent(s) or their combination to the overall extract biological activity. Gas chromatography/mass spectroscopy analysis showed that the extract contained monoterpene hydrocarbons and phenolic compounds, the major ones being carvacrol and thymol and to a lesser extent p-cymene, 1-Octacosanol, creosol, and phytol. A549 epithelial cells challenged with the extract showed a concentration-dependent increase in cytotoxicity. A combination of thymol and carvacrol at equimolar concentrations to those present in the extract was less cytotoxic. The A549 cells pretreated with nonlethal extract concentrations protected against hydrogen-peroxide-induced cytotoxicity, an antioxidant effect more effective than the combination of equimolar concentrations of thymol/carvacrol. Inclusion of p-cymene and/or 1-Octacosanol did not alter the synergistic antioxidant effects of the carvacrol/thymol mixture. The extract also exhibited antimicrobial properties against Gram-positive and Gram-negative bacterial strains including clinical isolates.
CONCLUSIONS:
In conclusion, the oregano extract has cytotoxic, antioxidant, and antibacterial activities mostly attributed to carvacrol and thymol.

Protocol of 1-Octacosanol

Kinase Assay

Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants.[Pubmed: 28756918 ]

Asian Pac J Trop Med. 2017 Jun;10(6):549-556.

To screen Vietnamese medicinal plants for xanthine oxidase (XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant.
METHODS AND RESULTS:
The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. Three hundreds and eleven methanol extracts (CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 μg/mL with inhibition rates of over 50%. The extracts of Archidendron clypearia (A. clypearia), Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC50 values below 30 μg/mL. Chemical study performed on the extract of A. clypearia resulted in the isolation of six compounds, including 1-Octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and (-)-7-O-galloyltricetiflavan. The compound (-)-7-O-galloyltricetiflavan showed the most potent XO inhibitory activity with an IC50 value of 25.5 μmol/L.
CONCLUSIONS:
From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC50 values of the methanol extracts below 30 μg/mL. Compound (-)-7-O- galloyltricetiflavan was identified as an XO inhibitor from A. clypearia with IC50 value of 25.5 μmol/L.

1-Octacosanol Dilution Calculator

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1-Octacosanol Molarity Calculator

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Preparing Stock Solutions of 1-Octacosanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4345 mL 12.1726 mL 24.3451 mL 48.6902 mL 60.8628 mL
5 mM 0.4869 mL 2.4345 mL 4.869 mL 9.738 mL 12.1726 mL
10 mM 0.2435 mL 1.2173 mL 2.4345 mL 4.869 mL 6.0863 mL
50 mM 0.0487 mL 0.2435 mL 0.4869 mL 0.9738 mL 1.2173 mL
100 mM 0.0243 mL 0.1217 mL 0.2435 mL 0.4869 mL 0.6086 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1-Octacosanol

Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants.[Pubmed:28756918]

Asian Pac J Trop Med. 2017 Jun;10(6):549-556.

OBJECTIVE: To screen Vietnamese medicinal plants for xanthine oxidase (XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. METHODS: The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. RESULTS: Three hundreds and eleven methanol extracts (CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 mug/mL with inhibition rates of over 50%. The extracts of Archidendron clypearia (A. clypearia), Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC50 values below 30 mug/mL. Chemical study performed on the extract of A. clypearia resulted in the isolation of six compounds, including 1-Octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and (-)-7-O-galloyltricetiflavan. The compound (-)-7-O-galloyltricetiflavan showed the most potent XO inhibitory activity with an IC50 value of 25.5 mumol/L. CONCLUSIONS: From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC50 values of the methanol extracts below 30 mug/mL. Compound (-)-7-O- galloyltricetiflavan was identified as an XO inhibitor from A. clypearia with IC50 value of 25.5 mumol/L.

Description

1-Octacosanol is a straight-chain aliphatic 28-carbon fatty alcohol with well-known anti-fatigue function.

Keywords:

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