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Aristololactam II

CAS# 55610-00-9

Aristololactam II

Catalog No. BCN8095----Order now to get a substantial discount!

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Quality Control of Aristololactam II

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Chemical structure

Aristololactam II

3D structure

Chemical Properties of Aristololactam II

Cas No. 55610-00-9 SDF Download SDF
PubChem ID 148745 Appearance Powder
Formula C16H9NO3 M.Wt 263.25
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES C1OC2=C(O1)C3=C4C(=C2)C(=O)NC4=CC5=CC=CC=C53
Standard InChIKey KPVDACWQNCRKTG-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H9NO3/c18-16-10-6-12-15(20-7-19-12)14-9-4-2-1-3-8(9)5-11(17-16)13(10)14/h1-6H,7H2,(H,17,18)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aristololactam II

The herbs of Aristolochia debilis

Biological Activity of Aristololactam II

In vitro

Studies on morphology and aristolochic acid analogue constituents of Asarum campaniflorum and a comparison with two official species of Asari radix et rhizoma.[Pubmed: 20640524]

J Nat Med. 2010 Oct;64(4):442-51.

Dried whole herbs or roots and rhizomes of Asarum campaniflorum have been sold under the trade name Xixin and used as folk remedies in its producing areas for a long time. In order to avoid the misuse of A. campaniflorum as official species of Xixin (Asari radix et rhizoma), a comparative study based on the morphological and phytochemical analysis of the aerial and underground parts was carried out.
METHODS AND RESULTS:
The usual morphological methods and a microscopic imaging system were used. The results show that A. campaniflorum could be easily distinguished from two official species (Asarum sieboldii and A. heterotropoides var. mandshuricum) by the diameter of thicker roots (1.3-2.7 mm), distinct large parenchymatous cells in phloem of roots, and the size of oil cells in upper leaf epidermises [(40)80-140(174) microm in diameter, where numbers in parentheses are for rare cases], etc. Nine aristolochic acid analogues (AAAs) were identified and estimated by high-performance liquid chromatography-diode array detection (HPLC-DAD). The aerial and underground parts of A. campaniflorum contained 3-4 AAAs, i.e., aristololactam-II-N-beta-D-glucoside (AL-II-Glc), aristololactam I (AL-I), Aristololactam II (AL-II), and aristolochic acid I (AA-I), while only AL-I was detected in underground parts of A. sieboldii and no AAAs were detected in underground parts of A. heterotropoides var. mandshuricum. The respective contents (in mg/g) in aerial and underground parts of A. campaniflorum, were as follows: AL-I, 0.06-0.12, 0.05-0.10; AL-II, 0.03-0.04, 0.01-0.03; AA-I, 0.01-0.02, 0.0-0.0.
CONCLUSIONS:
These data suggest A. campaniflorum has a high risk of causing aristolochic acid nephropathy. All these discoveries can contribute to not only the better understanding of this new resource species, but also the safe use of the crude drug Xixin.

Protocol of Aristololactam II

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2010 Nov;35(21):2862-5.

Chemical constituent from fruit of Aristolochia contorta.[Pubmed: 21322947]

To study the chemical constituents of the fruit of Aristolochia contorta.
METHODS AND RESULTS:
The compounds were isolated by chromatographic techniques and crystalization, the structures were elucidated by spectrum analysis. Fifteen compounds were isolated from the dry fruit of A. contorta, which were six aristolochic acids: aristolochic acid I, aristolochic acid III a, aristolochic acid IVa, aristolochic acid II, aristolochic acid III and aristolochic acid VIIa. Three aristolactams: aristololactam I, Aristololactam II and Aristololactam IIIa. Three phenolic acids syringic acid, vanillic acid and p-coumaric acid. Three other type compounds: pentacosane acid, beta-sitosterol and daucossterol.
CONCLUSIONS:
Aristolochic acid III, aristolochic acid VIIa, Aristololactam IIIa, and penfacosane acid were isolated from A. contorta for the first time, and compounds 4-13 were isolated from the furit of A. contorta for the first time.

Aristololactam II Dilution Calculator

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Aristololactam II Molarity Calculator

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Preparing Stock Solutions of Aristololactam II

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7987 mL 18.9934 mL 37.9867 mL 75.9734 mL 94.9668 mL
5 mM 0.7597 mL 3.7987 mL 7.5973 mL 15.1947 mL 18.9934 mL
10 mM 0.3799 mL 1.8993 mL 3.7987 mL 7.5973 mL 9.4967 mL
50 mM 0.076 mL 0.3799 mL 0.7597 mL 1.5195 mL 1.8993 mL
100 mM 0.038 mL 0.1899 mL 0.3799 mL 0.7597 mL 0.9497 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aristololactam II

[Chemical constituent from fruit of Aristolochia contorta].[Pubmed:21322947]

Zhongguo Zhong Yao Za Zhi. 2010 Nov;35(21):2862-5.

OBJECTIVE: To study the chemical constituents of the fruit of Aristolochia contorta. METHOD: The compounds were isolated by chromatographic techniques and crystalization, the structures were elucidated by spectrum analysis. RESULT: Fifteen compounds were isolated from the dry fruit of A. contorta, which were six aristolochic acids: aristolochic acid I, aristolochic acid III a, aristolochic acid IVa, aristolochic acid II, aristolochic acid III and aristolochic acid VIIa. Three aristolactams: aristololactam I, Aristololactam II and Aristololactam IIIa. Three phenolic acids syringic acid, vanillic acid and p-coumaric acid. Three other type compounds: pentacosane acid, beta-sitosterol and daucossterol. CONCLUSION: Aristolochic acid III, aristolochic acid VIIa, Aristololactam IIIa, and penfacosane acid were isolated from A. contorta for the first time, and compounds 4-13 were isolated from the furit of A. contorta for the first time.

Studies on morphology and aristolochic acid analogue constituents of Asarum campaniflorum and a comparison with two official species of Asari radix et rhizoma.[Pubmed:20640524]

J Nat Med. 2010 Oct;64(4):442-51.

Dried whole herbs or roots and rhizomes of Asarum campaniflorum have been sold under the trade name Xixin and used as folk remedies in its producing areas for a long time. In order to avoid the misuse of A. campaniflorum as official species of Xixin (Asari radix et rhizoma), a comparative study based on the morphological and phytochemical analysis of the aerial and underground parts was carried out. The usual morphological methods and a microscopic imaging system were used. The results show that A. campaniflorum could be easily distinguished from two official species (Asarum sieboldii and A. heterotropoides var. mandshuricum) by the diameter of thicker roots (1.3-2.7 mm), distinct large parenchymatous cells in phloem of roots, and the size of oil cells in upper leaf epidermises [(40)80-140(174) microm in diameter, where numbers in parentheses are for rare cases], etc. Nine aristolochic acid analogues (AAAs) were identified and estimated by high-performance liquid chromatography-diode array detection (HPLC-DAD). The aerial and underground parts of A. campaniflorum contained 3-4 AAAs, i.e., aristololactam-II-N-beta-D-glucoside (AL-II-Glc), aristololactam I (AL-I), Aristololactam II (AL-II), and aristolochic acid I (AA-I), while only AL-I was detected in underground parts of A. sieboldii and no AAAs were detected in underground parts of A. heterotropoides var. mandshuricum. The respective contents (in mg/g) in aerial and underground parts of A. campaniflorum, were as follows: AL-I, 0.06-0.12, 0.05-0.10; AL-II, 0.03-0.04, 0.01-0.03; AA-I, 0.01-0.02, 0.0-0.0. These data suggest A. campaniflorum has a high risk of causing aristolochic acid nephropathy. All these discoveries can contribute to not only the better understanding of this new resource species, but also the safe use of the crude drug Xixin.

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