Agrimol BCAS# 55576-66-4 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 55576-66-4 | SDF | Download SDF |
| PubChem ID | 194000 | Appearance | Powder |
| Formula | C37H46O12 | M.Wt | 682.75 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S)-1-[3,5-bis[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylphenyl)methyl]-2,4,6-trihydroxyphenyl]-2-methylbutan-1-one | ||
| SMILES | CCCC(=O)C1=C(C(=C(C(=C1O)CC2=C(C(=C(C(=C2O)C(=O)C(C)CC)O)CC3=C(C(=C(C(=C3O)C)OC)C(=O)CCC)O)O)O)C)OC | ||
| Standard InChIKey | BVLHMPZMQVWDGX-INIZCTEOSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Agrimol B has antibacterial activity against Pseudomonas syringae pv. lacrymans (bacterial leaf spot pathogen), Ralstonia solanacearum (tomato bacterial wilt pathogen) and Pseudomonas syringae pv. tabaci (Tobacco wild fire pathogen). Agrimol B has a therapeutic potential on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway. |
| Targets | PPAR | Antifection |
| In vitro | Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB.[Reference: WebLink]The Korean Journal of Pesticide Science,2006, 10(3):230-6.
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| Kinase Assay | Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.[Pubmed: 27320865]Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60.Studies of human genetics have implicated the role of SIRT1 in regulating obesity, insulin resistance, and longevity. These researches motivated the identification of novel SIRT1 activators. |
| Structure Identification | Biomed Chromatogr. 2015 Apr;29(4):481-4.Development of a liquid chromatography-mass spectrometry method for determination of agrimol B in rat plasma: application to preclinical pharmacokinetics.[Pubmed: 25065576]A sensitive and accurate liquid chromatography coupled with mass spectrometry (LC-MS) method was developed for the determination of Agrimol B, a main active ingredient isolated from Agrimonia pilosa Ledeb., in rat plasma. |
Agrimol B Dilution Calculator
Agrimol B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4647 mL | 7.3233 mL | 14.6466 mL | 29.2933 mL | 36.6166 mL |
| 5 mM | 0.2929 mL | 1.4647 mL | 2.9293 mL | 5.8587 mL | 7.3233 mL |
| 10 mM | 0.1465 mL | 0.7323 mL | 1.4647 mL | 2.9293 mL | 3.6617 mL |
| 50 mM | 0.0293 mL | 0.1465 mL | 0.2929 mL | 0.5859 mL | 0.7323 mL |
| 100 mM | 0.0146 mL | 0.0732 mL | 0.1465 mL | 0.2929 mL | 0.3662 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Development of a liquid chromatography-mass spectrometry method for determination of agrimol B in rat plasma: application to preclinical pharmacokinetics.[Pubmed:25065576]
Biomed Chromatogr. 2015 Apr;29(4):481-4.
A sensitive and accurate liquid chromatography coupled with mass spectrometry (LC-MS) method was developed for the determination of Agrimol B, a main active ingredient isolated from Agrimonia pilosa Ledeb., in rat plasma. Chromatographic separation was achieved on a Zorbax CN column (150 x 4.6 mm, 5 microm), with isocratic elution consisting of acetonitrile and water (15:85, v/v) at a flow rate of 0.6 mL/min. Agrimol B and dryocrassin ABBA, an internal standard (IS), were analyzed by selected ion monitoring at m/z transitions of 681.3 and 819.4, respectively. This assay exhibited a good linearity with a correlation coefficient >0.99 and showed no endogenous interference with the analyte and IS. The limit of quantification of Agrimol B was 8.025 ng/mL with acceptable precision and accuracy. The method was successfully applied in the pharmacokinetic study of Agrimol B in rats after intravenous (1 mg/kg) and oral (2, 5 and 10 mg/kg) doses of Agrimol B. The absolute bioavailability of Agrimol B was 16.4-18.0% in rat. Our study clarifies the pharmacokinetic behavior of Agrimol B in animals.
Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.[Pubmed:27320865]
Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60.
Studies of human genetics have implicated the role of SIRT1 in regulating obesity, insulin resistance, and longevity. These researches motivated the identification of novel SIRT1 activators. The current study aimed to investigate the potential efficacy of Agrimol B, a polyphenol derived from Agrimonia pilosa Ledeb., on mediating SIRT1 activity and fat metabolism. Results showed that Agrimol B significantly induced cytoplasm-to-nucleus shuttle of SIRT1. Furthermore, we confirmed that Agrimol B dramatically inhibited 3T3-L1 adipocyte differentiation by reducing PPARgamma, C/EBPalpha, FAS, UCP-1, and apoE expression. Consequently, adipogenesis was blocked by treatment of Agrimol B at the early stage of differentiation in a dose-dependent manner, the IC50 value was determined as 3.35 +/- 0.32 muM. Taken together, our data suggest a therapeutic potential of Agrimol B on alleviating obesity, through modulation of SIRT1-PPARgamma signal pathway.
