Natural Products from Lepidium meyenii

Natural Products Isolated from Lepidium meyenii

BioCrick provides high-purity natural products and bioactive compounds isolated and purified from natural sources for scientific research.

  • Natural product compounds selected from diverse chemical and biological sources.
  • Broad structural diversity and coverage of biological activities.
  • Product activity information can be supported by published literature, patents and research reports.
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Natural Products from Lepidium meyenii

9 natural product s associated with Lepidium meyenii

Natural products and bioactive compounds from Lepidium meyenii
Catalog No. Product Name CAS Number COA
BCN1518 (9Z,12Z)-N-Benzyloctadeca-9,12-dienamide
(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide chemical structure
18286-71-0 COA
BCN8173 13-Oxo-9E,11E-octadecadienoic acid
13-Oxo-9E,11E-octadecadienoic acid chemical structure
29623-29-8 COA
BCN4546 4-Hydroxybenzoic acid
4-Hydroxybenzoic acid chemical structure
99-96-7 COA
BCN8319 alpha-Linolenic acid
alpha-Linolenic acid chemical structure
463-40-1 COA
BCN9069 Benzyl alcohol
Benzyl alcohol chemical structure
100-51-6 COA
BCC3138 H-Val-OH
H-Val-OH chemical structure
72-18-4 COA
BCN3821 Linoleic acid
Linoleic acid chemical structure
60-33-3 COA
BCN1366 Macamide B
Macamide B chemical structure
74058-71-2 COA
BCN6531 N-Benzyllinolenamide
N-Benzyllinolenamide chemical structure
883715-18-2 COA

References

Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides.[Pubmed: 29926378]


The pentane extract of the Peruvian plant, Lepidium meyenii (Maca), has been demonstrated to possess neuroprotective activity in previous in vitro and in vivo studies (Pino-Figueroa et al. in Ann N Y Acad Sci 1199:77-85, 2010; Pino-Figueroa et al. in Am J Neuroprot Neuroregener 3:87-92, 2011). This extract contains a number of macamides that may act on the endocannabinoid system (Pino-Figueroa et al. in Ann N Y Acad Sci 1199:77-85, 2010; Pino-Figueroa et al., 2011; Dini et al. in Food Chem 49:347-349, 1994). The aim of this study was to characterize the inhibitory activity of four of these maccamides (N-benzylstearamide, N-benzyloleamide, N-benzyloctadeca-9Z,12Z-dienamide, and N-benzyloctadeca-9Z,12Z,15Z-trienamide) on fatty acid amide hydrolase (FAAH), an enzyme that is responsible for endocannabinoid degradation in the nervous system (Kumar et al. in Anaesthesia 56:1059-1068, 2001). The four compounds were tested at concentrations between 1 and 100 μM, utilizing an FAAH inhibitor screening assay. The results demonstrated concentration-dependent FAAH inhibitory activities for the four macamides tested. N-Benzyloctadeca-9Z,12Z-dienamide demonstrated the highest FAAH inhibitory activity whereas N-benzylstearamide had the lowest inhibitory activity. In addition, N-benzylstearamide, N-benzyloleamide, and N-benzyloctadeca-9Z,12Z-dienamide demonstrated time-dependent inhibition when tested after a pre-incubation period, indicating that the mechanism of inhibition for these compounds most likely is irreversible. Of interest, unsaturation in the fatty acid moiety resulted in greater FAAH inhibitory activity. LC/MS/MS analysis demonstrated that FAAH was able to hydrolyze N-benzyloctadeca-9Z,12Z-dienamide, suggesting that N-benzyloctadeca-9Z,12Z-dienamide is also a slow substrate for FAAH. These results provide useful information about the mechanism of action of Lepidium meyenii and may help with the development of new compounds with FAAH inhibitory or modulatory activity.