Natural Products from Morus yunnanensis
Natural Products Isolated from Morus yunnanensis
BioCrick provides high-purity natural products and bioactive compounds isolated and purified from natural sources for scientific research.
- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
- Product activity information can be supported by published literature, patents and research reports.
- Natural products can be selected according to source, target, activity and disease research interests.
- Compounds should be stored according to the product specifications after receipt.
Natural Products from Morus yunnanensis
1 natural product associated with Morus yunnanensis
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN6344 |
Mulberroside C
|
102841-43-0 | COA |
References
(2S)-7,4'-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells.[Pubmed: 25797620]
Adipose tissue plays a key role in the development of obesity and diabetes. Natural products are one of the main sources for discovering new lead compounds. In the present study, (2S)-7,4'-dihydroxy-8-prenylflavan (DHPF), a natural prenylated flavan isolated from Morus yunnanensis, was found to significantly promote adipogenesis and increase glucose uptake in 3T3-L1 cells. Real-time PCR results showed that DHPF increased the expression of glucose and lipid metabolism-related genes (C/EBPα, PPARγ, aP2, GLUT4 and adiponectin) and decreased the expression of inflammatory cytokine TNF-α. Western blotting further revealed that DHPF activated p38 MAPK at the initial stage of 3T3-L1 preadipocyte differentiation. DHPF-induced activation of p38, adipogenesis and glucose uptake were effectively blocked by SB203580, a specific p38 inhibitor. These results indicate that DHPF could stimulate adipogenesis and increase glucose uptake through the p38 MAPK pathway, and DHPF may be useful for the prevention and treatment of obesity-associated disorders such as type 2 diabetes (T2D).
[Isoprenylated phenolic compounds from leaves of Morus yunnanensis].[Pubmed: 24010287]
Phytochemical investigation on an EtOH extract of the leaves of Mons yunnanensis led to the isolation and characterization of 11 isoprenylated phenolic compounds, morusyunnansin G (1), morachalcone B (2), cudraxanthone M (3), cudraxanthone D (4), sanggenofuran B(5), moracin D (6), moracin C (7), moracin I (8), demethylmoracin I (9), morachalcone A (10), and isobacachalcone (11). Compound 1 is a new compound and compounds 2-11 were isolated from this plant for the first time.
2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis.[Pubmed: 22165973]
Two novel 2-arylbenzofuran dimers, morusyunnansins A and B (1 and 2), two new biflavonoids, morusyunnansins C and D (3 and 4), two new flavans, morusyunnansins E and F (5 and 6), and four known flavans (7-10) were isolated from the leaves of Morus yunnanensis. Compounds 5-8 showed potent inhibitory effects on mushroom tyrosinase with IC(50) values ranging from 0.12 ± 0.02 to 1.43 ± 0.43 μM.