A tetracyclic triterpenoid that is dammarane which has a double bond between positions 24 and 25, and is substituted by hydroxy groups at the 3β- and 20- positions.
InChI=1S/C30H52O2/c1-20(2)10-9-16-30(8,32)22-13-18-28(6)21(22)11-12-24-27(5)17-15-25(31)26(3,4)23(27)14-19-29(24,28)7/h10,21-25,31-32H,9,11-19H2,1-8H3/t21?,22?,23-,24+,25-,27-,28+,29+,30-/m0/s1
Dammarenediol-II synthase is a key rate-limiting enzyme during the process of rice synthesizes dammarane-type ginsenosides.[1]
Dammarenediol-II can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber formation and vascular endothelial-cadherin disruption, suggests that the natural drug dammarenediol-II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy.[2]
The medicinally important dammarenediol-II can be ectopically produced in tobacco, and the production of dammarenediol-II in tobacco plants allows them to adopt a viral defense system.[3]
English website: Dammarenediol II
Japanese website: Dammarenediol II
Chinese website: Dammarenediol II
[1] Huang Z, Lin J, Cheng Z, et al. Plant Sci, 2015, 239:106-14.
[2] Su-Hyeon Kim †, Se-Hui Jung †, Lee Y J, et al. Phytother Res, 2015, 29(12):1910–6.
[3] Lee M H, Han J Y, Kim H J, et al. Plant Cell Physiol, 2012, 53(1):173-82.
