InChI=1S/C15H10O6/c16-5-6-1-8-12(10(18)2-6)15(21)13-9(14(8)20)3-7(17)4-11(13)19/h1-4,16-19H,5H2
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells, it represents a potential therapeutic approach for the treatment of inflammatory diseases.[1]
Citreorosein attenuates degranulation and LTC 4 generation through the suppression of multiple step signaling and would be beneficial for the prevention of allergic inflammation.[2]
Bioassay directed isolation of C. nigricans leaf extract yielded anthraquinones emodin, citreorosein, and emodic acid and a flavonoid, luteolin, they can kill mosquito larvae Anopheles gambiaea adult B. tabaci, thus the extract of C. nigricans has the potential to be used as an organic approach to manage some of the agricultural pests.[3]
English website: Citreorosein
Japanese website: Citreorosein
Chinese website: Citreorosein
[1] Lu Y, Suh S J, Li X, et al. Food Chem Toxicol , 2012, 50(3–4):913-9.
[2] Lu Y, Li Y, Jahng Y, et al. Mol Cell Biochem, 2012, 365(1-2):333-41.
[3] Jing L L, Cha H C, Lee S H, et al. Arch Pharm Res, 2012, 35(3):447-54.
[4] Manojlovic N T, Vasiljevic P J, Gritsanapan W, et al. Biol Res 2010, 43(43):169-76.
