A dimethoxyflavone that is the 6,4'-dimethyl ether derivative of scutellarein.

InChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)13-7-11(18)15-14(23-13)8-12(19)17(22-2)16(15)20/h3-8,19-20H,1-2H3

Pectolinarin and pectolinarigenin exhibit hepatoprotective activity mainly via SOD antioxidant mechanism, can prevent the hepatic injury in rats caused by D-galactosamine.[1]
Pectolinarigenin and pectolinarin possess anti-inflammatory activity and that they may inhibit eicosanoid formation in inflammatory lesions. [2]
Pectolinarigenin inhibits breast cancer stem cell-like properties and lowers the chemoresistance of the cancer cells to chemotherapy, the results provide an insight into the mechanism of the anti-breast tumor effects and an experimental basis for the use of pectolinarigenin to enhance treatment of patients with breast cancer.[3]
Pectolinarigenin shows potent anti-proliferation activity by inducing apoptosis and downregulation of Bcl2 expression in MCF-7 breast cancer cell; protein expression of Bcl2 is almost completely inhibited upon the treatment with 25 mM pectolinarigenin. [4]

English website: Pectolinarigenin
Japanese website: Pectolinarigenin
Chinese website: Pectolinarigenin

[1] Yoo Y M, Nam J H, Kim M Y, et al. Biol Pharm Bull, 2008, 31(4):760-4.
[2] Lim H, Son K H, Chang H W, et al. Biol Pharm Bull, 2008, 31(11):2063-7.
[3] Lu M, Xu X, Lu H, et al. Tropi J Pharm Res, 2016, 15(3):547-53.
[4] Lu M, Kong Q, Xu X, et al. Tropi J Pharm Res, 2014, 13(2):225-8.
[5] Sakpakdeejaroen I, Juckmeta T, Itharat A. J Med Assoc Thai. 2014 Aug;97 Suppl 8:S76-80.