An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20.

20-hydroxyecdysone slowly reduces food consumption and then indirectly induces a state of starvation resulting in the elevation of the mRNA levels of InR , IRS , PI3K110 , and PDK in the Bombyx fat body during molting and pupation, and 20-hydroxyecdysone inhibits innate immunity in the fat body during Bombyx postembryonic development.[1,2]
20-hydroxyecdysone acts as both a positive and a negative regulator of EDG transcription, sequences in the promoter regions of two of the EDGs are similar to an ecdysone response element and may play a role in negative regulation.[3]
20-hydroxyecdysone can block TORC1 activity for autophagosome initiation, and upregulates Atg genes to induce autophagy in the Bombyx fat body.[4]

English website: 20-Hydroxyecdysone
Japanese website: 20-Hydroxyecdysone
Chinese website: 20-Hydroxyecdysone

[1] Ling T, Guo E, Diao Y, et al. Bmc Genomics, 2010, 11(1):1-12.
[2] Yan L, Zhou S, Li M, et al. J Insect Physiol, 2010, 56(10):1436-44.
[3] Apple R T, Fristrom J W. Dev Biol, 1991, 146(2):569-82.
[4] Tian L, Ma L, Guo E, et al. Autophagy, 2013, 9(8):1172-87.
[5] Kim J H, Kim J M, Kang D H. ResearchGate, 2008, 23(1).