Cucurbitacin A

Catalog No.	BCN2468
CAS RN	6040-19-3
Molecular Weight	574.71
Molecular Formula	C32H46O9
Database	[PubChem]:382163045 [ChEBI]:3940 [PCIDB]:3682

Definition

Standard InChI

InChI=1S/C32H46O9/c1-17(34)41-27(2,3)12-11-23(37)31(8,40)25-21(36)14-29(6)22-10-9-18-19(13-20(35)26(39)28(18,4)5)32(22,16-33)24(38)15-30(25,29)7/h9,11-12,19-22,25,33,35-36,40H,10,13-16H2,1-8H3/b12-11+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1

Biological Activity

Cucurbitacin I , cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.[1]

Product information

English website: Cucurbitacin A
Japanese website: Cucurbitacin A
Chinese website: Cucurbitacin A

References

[1] Hassoun M S, Clement M J, Hamdi I, et al. Biochem Pharmacol, 2015, 102:45-63.
[2] Peng Z X, Cao M, Zhang Y J, et al. Chinese J Modern Applied Pharm, 2009 (11): 946-8.