Cucurbitacin A

CAS# 6040-19-3

Cucurbitacin A

Catalog No. BCN2468----Order now to get a substantial discount!

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Cucurbitacin A: 5mg $512 In Stock
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Quality Control of Cucurbitacin A

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Chemical structure

Cucurbitacin A

3D structure

Chemical Properties of Cucurbitacin A

Cas No. 6040-19-3 SDF Download SDF
PubChem ID 5281315 Appearance White powder
Formula C32H46O9 M.Wt 574.71
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in chloroform; insoluble in water
Chemical Name [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
SMILES CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)CO)C)C)O)O
Standard InChIKey IHTCCHVMPGDDSL-IVNGUWCNSA-N
Standard InChI InChI=1S/C32H46O9/c1-17(34)41-27(2,3)12-11-23(37)31(8,40)25-21(36)14-29(6)22-10-9-18-19(13-20(35)26(39)28(18,4)5)32(22,16-33)24(38)15-30(25,29)7/h9,11-12,19-22,25,33,35-36,40H,10,13-16H2,1-8H3/b12-11+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cucurbitacin A

1 Maprounea sp.

Biological Activity of Cucurbitacin A

Description1. Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
TargetsROCK

Cucurbitacin A Dilution Calculator

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Cucurbitacin A Molarity Calculator

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Preparing Stock Solutions of Cucurbitacin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.74 mL 8.7 mL 17.4001 mL 34.8002 mL 43.5002 mL
5 mM 0.348 mL 1.74 mL 3.48 mL 6.96 mL 8.7 mL
10 mM 0.174 mL 0.87 mL 1.74 mL 3.48 mL 4.35 mL
50 mM 0.0348 mL 0.174 mL 0.348 mL 0.696 mL 0.87 mL
100 mM 0.0174 mL 0.087 mL 0.174 mL 0.348 mL 0.435 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cucurbitacin A

Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.[Pubmed:26707799]

Biochem Pharmacol. 2016 Feb 15;102:45-63.

Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin associated with blockage of cell migration and division that eventually lead to apoptosis. We unravel here that cucurbitacin I actually induces the co-aggregation of actin with phospho-myosin II. This co-aggregation most probably results from the stimulation of the Rho/ROCK pathway and the direct inhibition of the LIMKinase. We further provide data that suggest that the formation of these co-aggregates is independent of a putative pro-oxidant status of cucurbitacin I. The results help to understand the impact of cucurbitacins on signal transduction and actin dynamics and open novel perspectives to use it as drug candidates for cancer research.

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