Zimelidine dihydrochlorideSelective 5-HT uptake inhibitor CAS# 60525-15-7 |
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Quality Control & MSDS
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| Cas No. | 60525-15-7 | SDF | Download SDF |
| PubChem ID | 6436006 | Appearance | Powder |
| Formula | C16H19BrCl2N2 | M.Wt | 390.15 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water | ||
| Chemical Name | (Z)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-3-ylprop-2-en-1-amine;dihydrochloride | ||
| SMILES | CN(C)CC=C(C1=CC=C(C=C1)Br)C2=CN=CC=C2.Cl.Cl | ||
| Standard InChIKey | CXGURXWCQYHDIR-ULPVBNQHSA-N | ||
| Standard InChI | InChI=1S/C16H17BrN2.2ClH/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;/h3-10,12H,11H2,1-2H3;2*1H/b16-9-;; | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC50 values are 0.33, 8.2 and 12 μM respectively). Modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant. |
Zimelidine dihydrochloride Dilution Calculator
Zimelidine dihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5631 mL | 12.8156 mL | 25.6312 mL | 51.2623 mL | 64.0779 mL |
| 5 mM | 0.5126 mL | 2.5631 mL | 5.1262 mL | 10.2525 mL | 12.8156 mL |
| 10 mM | 0.2563 mL | 1.2816 mL | 2.5631 mL | 5.1262 mL | 6.4078 mL |
| 50 mM | 0.0513 mL | 0.2563 mL | 0.5126 mL | 1.0252 mL | 1.2816 mL |
| 100 mM | 0.0256 mL | 0.1282 mL | 0.2563 mL | 0.5126 mL | 0.6408 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Different effects of zimelidine on the reinforcing properties of d-amphetamine and morphine on conditioned place preference in rats.[Pubmed:2943599]
Eur J Pharmacol. 1986 Jun 17;125(2):283-6.
The possibility that serotoninergic mechanisms control the reinforcing properties of d-amphetamine and morphine was investigated in rats, using zimelidine, a potent and selective serotonin uptake blocker and the conditioned place preference test design. Zimelidine dihydrochloride 20 mg/kg did not cause place aversion and did not modify the place preference induced by 5 mg/kg morphine hydrochloride. Place preference induced by 5 mg/kg d-amphetamine sulphate was completely blocked by pretreatment with zimelidine. The results suggest that the reinforcing properties of d-amphetamine, but not of opioid agonists, may be reduced by agents which increase serotonin transmission in the brain.
Involvement of serotonin in zimelidine-induced hyperglycemia in mice.[Pubmed:10598036]
Biol Pharm Bull. 1999 Nov;22(11):1240-1.
Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-HT depleter p-chlorophenylalanine(pCPA) were examined. pCPA significantly reduced zimelidine-induced hyperglycemia. This suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-HT reuptake inhibition.
Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and the substance P behavioural assay.[Pubmed:2438584]
Neuropharmacology. 1987 Apr;26(4):309-12.
The selective inhibitor of the reuptake of 5-hydroxytryptamine (5-HT), zimelidine, was administered intraperitoneally to mice (10 mg/kg) and nociceptive sensitivity was evaluated using the formalin test (20 microliters of 1% formalin, injected subcutaneously) and the assay for substance P (5 ng administered intrathecally). Zimelidine increased the behavioural response to formalin, but reduced the response to substance P. These effects of zimelidine seemed to be unchanged after chronic treatment (2 X 10 mg/kg for 14 days). It is suggested that zimelidine produces a central antinociceptive effect, but elicits a peripheral hyperalgesia, which predominates in the formalin test.
