Hot Natural Products & Bioactive Compounds

1. Gancaonin I exhibits anti-BsFtsZ GTPase activities.
2. Gancaonin I shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM.

1. Diammonium glycyrrhizinate shows antiviral effect on cell infection by pseudorabies herpesvirus.
2. Diammonium Glycyrrhizinate can reduce inflammatory injury in a rat model of ulcerative colitis, this may occur via suppression of NF-kappaB, TNF-alpha and ICAM-1 in colonic mucosa.
3. Diammonium glycyrrhizinate may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way.
4. Diammonium glycyrrhizinate can attenuate Aβ(1-42)-induced neuronal injury by preventing mitochondrial dysfunction and oxidative stress and improve cognitive impairment in Aβ(1-42)-induced AD mice, indicating that it exerts potential beneficial effects on AD.
5. Diammonium glycyrrhizinate can inhibit airway smooth muscle proliferation possibly through up- regulation of PPARγ in a murine model of chronic asthma.

Irenolone is a natural product from Musa itinerans Cheesm.

1. Alternariol, a mycotoxin, is found in food and beverages infected by Alternaria alternata, it shows estrogenic potential, inhibition of cell proliferation and clastogenicity in Ishikawa and V79 cells in vitro.
2. Alternariol possesses genotoxic properties, it is a poison of topoisomerase I and II with a certain selectivity for the II isoform.
3. Alternariol has strong activities against KB and KBv200 cells with IC 50 values of 3.17, 3.12 ug/mL.
4. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages.
5. Alternariol is a new phototoxic, DNA-intercalating agent and is a DNA cross-linking mycotoxin in near UV light.

1. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis.
2. Diisobutyl phthalate administered by gavage is embryotoxic and teratogenic, and affects the developing male reproductive tract, at maternal toxic doses.
3. Diisobutyl phthalate could through blood-brain barrier after oral intake, and disordered the way of apoptosis of hippocampal cells, and morphologic change of mitochondria mybe is the main reason of changes of neuron apoptosis.
4. Diisobutyl phthalate induced oxidative stress, which can decrease the activities of antioxidative enzymes and result in oxidative damage of tissues.

1. Negundonorin A is strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 ug/mL.

3,4-seco-Olean-12-en-4-ol-3,28-dioic acid is a natural product from Ligularia intermedia.

Rotundanonic acid is a natural product from Ilex Rotunda.