Gancaonin ICAS# 126716-36-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 126716-36-7 | SDF | Download SDF |
| PubChem ID | 480777 | Appearance | Powder |
| Formula | C21H22O5 | M.Wt | 354.40 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[4,6-dimethoxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol | ||
| SMILES | CC(=CCC1=C(C=C2C(=C1OC)C=C(O2)C3=C(C=C(C=C3)O)O)OC)C | ||
| Standard InChIKey | DKVBYQAVNNRVNN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H22O5/c1-12(2)5-7-15-18(24-3)11-20-16(21(15)25-4)10-19(26-20)14-8-6-13(22)9-17(14)23/h5-6,8-11,22-23H,7H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Glycyrrhiza glabra.
| Description | 1. Gancaonin I exhibits anti-BsFtsZ GTPase activities. 2. Gancaonin I shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM. |
| Targets | Antifection |
Gancaonin I Dilution Calculator
Gancaonin I Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8217 mL | 14.1084 mL | 28.2167 mL | 56.4334 mL | 70.5418 mL |
| 5 mM | 0.5643 mL | 2.8217 mL | 5.6433 mL | 11.2867 mL | 14.1084 mL |
| 10 mM | 0.2822 mL | 1.4108 mL | 2.8217 mL | 5.6433 mL | 7.0542 mL |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.1287 mL | 1.4108 mL |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.5643 mL | 0.7054 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Gancaonin G
Catalog No.:BCN6837
CAS No.:126716-34-5
- Isoaltenuene
Catalog No.:BCN7313
CAS No.:126671-80-5
- UTPγS trisodium salt
Catalog No.:BCC7624
CAS No.:1266569-94-1
- KT 5823
Catalog No.:BCC7006
CAS No.:126643-37-6
- 16-Epinormacusine B
Catalog No.:BCN4030
CAS No.:126640-98-0
- A 887826
Catalog No.:BCC7898
CAS No.:1266212-81-0
- Trilobinine
Catalog No.:BCN7927
CAS No.:126595-92-4
- Vallesamine N-oxide
Catalog No.:BCN6144
CAS No.:126594-73-8
- Cyclocerberidol
Catalog No.:BCN6143
CAS No.:126594-66-9
- Cerberidol
Catalog No.:BCN6142
CAS No.:126594-64-7
- S1RA hydrochloride
Catalog No.:BCC4190
CAS No.:1265917-14-3
- 8,14-Epoxyergosta-4,22-diene-3,6-dione
Catalog No.:BCN1591
CAS No.:1265908-20-0
New Products
- Tilifodiolide
Catalog No.:BCN6145
CAS No.:126724-95-6
- Acetylsventenic acid
Catalog No.:BCN4849
CAS No.:126737-42-6
- Sarafotoxin S6a
Catalog No.:BCC5834
CAS No.:126738-34-9
- GR 89696 fumarate
Catalog No.:BCC7083
CAS No.:126766-32-3
- Sventenic acid
Catalog No.:BCN3923
CAS No.:126778-79-8
- Ulipristal acetate
Catalog No.:BCC4068
CAS No.:126784-99-4
- 5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone
Catalog No.:BCN1590
CAS No.:1268140-15-3
- 13-Acetoxy-3beta-hydroxygermacra-1(10)E,4E,7(11)-trien-12,6alpha-olide
Catalog No.:BCN7314
CAS No.:126829-66-1
- 8alpha-Acetoxyarglabin
Catalog No.:BCN7315
CAS No.:126829-70-7
- Bromodomain Inhibitor, (+)-JQ1
Catalog No.:BCC1132
CAS No.:1268524-70-4
- (-)-JQ1
Catalog No.:BCC3603
CAS No.:1268524-71-5
- MC 1046
Catalog No.:BCC1733
CAS No.:126860-83-1
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.[Pubmed:28196701]
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1420-1424.
FtsZ is an essential protein for bacterial cell division, and an attractive and underexploited novel antibacterial target protein. Screening of Indonesian plants revealed the inhibitory activity of the methanol extract of Glycyrrhiza glabra on the Bacillus subtilis FtsZ (BsFtsZ) GTPase, and further bioassay-guided fractionation of the active methanol extract led to the isolation of seven known polyketides (1-7). Among them, Gancaonin I (1), glycyrin (3), and isolicoflavanol (5) exhibited anti-BsFtsZ GTPase activities, at levels comparable to that of the synthetic FtsZ inhibitor, Zantrin Z3. Enzymatic assays using a BsFtsZ Val307R mutant protein and in silico simulations suggested that 1, 3, and 5 bind to the cleft on BsFtsZ, as in the case of the previously reported uncompetitive FtsZ inhibitor, PC190723, and thereby display their significant anti-BsFtsZ inhibitory activities. Furthermore, 1 also showed significant inhibitory activity against B. subtilis, with a MIC value of 5muM. The present study provides new insights into the naturally occurring B. subtilis growth inhibitors.
Gancaonin I,126716-36-7,Natural Products, buy Gancaonin I , Gancaonin I supplier , purchase Gancaonin I , Gancaonin I cost , Gancaonin I manufacturer , order Gancaonin I , high purity Gancaonin I
