Trilobinine

CAS# 126595-92-4

Trilobinine

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Quality Control of Trilobinine

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Chemical structure

Trilobinine

3D structure

Chemical Properties of Trilobinine

Cas No. 126595-92-4 SDF Download SDF
PubChem ID 124355908 Appearance Powder
Formula C20H24NO4+ M.Wt 342.41
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6aS)-2,9-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol
SMILES C[N+]1(CCC2=CC(=C(C3=C2C1CC4=CC(=CC(=C43)O)OC)O)OC)C
Standard InChIKey VTQUMUPOLNPVHP-AWEZNQCLSA-O
Standard InChI InChI=1S/C20H23NO4/c1-21(2)6-5-11-9-16(25-4)20(23)19-17(11)14(21)8-12-7-13(24-3)10-15(22)18(12)19/h7,9-10,14H,5-6,8H2,1-4H3,(H-,22,23)/p+1/t14-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Trilobinine

The herbs of Cocculus orbiculatus

Biological Activity of Trilobinine

Description1. (+)-Trilobinine has relaxant effects via the activation of beta 2-adrenoceptors, it can reduce the spontaneous tone and inhibit the contractions induced by carbachol and histamine.
TargetsAdrenergic Receptor

Trilobinine Dilution Calculator

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Trilobinine Molarity Calculator

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Preparing Stock Solutions of Trilobinine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9205 mL 14.6024 mL 29.2048 mL 58.4095 mL 73.0119 mL
5 mM 0.5841 mL 2.9205 mL 5.841 mL 11.6819 mL 14.6024 mL
10 mM 0.292 mL 1.4602 mL 2.9205 mL 5.841 mL 7.3012 mL
50 mM 0.0584 mL 0.292 mL 0.5841 mL 1.1682 mL 1.4602 mL
100 mM 0.0292 mL 0.146 mL 0.292 mL 0.5841 mL 0.7301 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Trilobinine

Tracheal relaxant activity of cissaglaberrimine and trilobinine, two aporphinic alkaloids from Cissampelos glaberrima.[Pubmed:10418339]

Planta Med. 1999 Jun;65(5):462-4.

In the present work we studied the relaxant effect of two aporphinic alkaloids isolated from the roots barks of Cissampelos glaberrima St. Hil. (Menispermaceae), (+)-cissaglaberrimine (CGE; a tertiary alkaloid) and (+)-Trilobinine (TBE; a quaternary alkaloid). In guinea-pig tracheal preparations, CGE and TBE reduced the spontaneous tone and inhibited the contractions induced by carbachol and histamine. TBE was 6 times more potent than CGE in reducing the spontaneous tone and it was also 1.5 times more potent in antagonising the effects of carbachol and histamine. The inhibitory effect of CGE in contractions induced by histamine was not attenuated in the presence of timolol (10 microM). However, in the same experimental conditions, timolol almost completely abolished the inhibitory effect of TBE. These results showed that the relaxations induced by TBE were dependent on the activation of beta 2-adrenoceptors, while the mechanism involved in relaxations induced by CGE remains to be determined.

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