Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN1189 | Alphitolic acid |
| 1. Alphitolic acid is an anti-inflammatory triterpene, has antitumour activity in oral squamous cell carcinoma (OSCC) cells. 2. Alphitolic acid can suppress the proliferation of SCC4 and SCC2095 OSCC cells with IC50 values of 12 and 15 uM, respectively, via apoptotic induction, this drug effect on apoptosis is, in part, associated with its ability to block Akt-NF-κB signalling; it could as an ingredient in functional food/dietary supplement for OSCC prevention. 3. Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells. 4. Alphitolic acid shows antimicrobial activity on Gram-positive bacteria and yeasts. 5. Alphitolic acid can inhibit NO release and iNOS expression in LPS-stimulated J774.A1 cultured macrophages. | |
| BCN1424 | Hordenine |
| Hordenine is an inhibitor of noradrenaline uptake, is also an effective inhibitor of hyperpigmentation. It can inhibit melanogenesis by suppressing cAMP production, which is involved in the expression of melanogenesis-related proteins. Hordenine also has a positive inotropic effect upon the heart, increases systolic and diastolic blood pressure, peripheral blood flow volume, inhibits gut movements. | |
| BCN1001 | Honokiol |
| Honokiol has antibacterial, anti-angiogenesis, antidepressant-like, antioxidant, anti-inflammatory and anti-cancer effects. It inhibited the activation of Akt and enhances the phosphorylation of ERK1/ERK2. It can improve learning, memory impairments and neuroinflammatory processes induced by SCOP in mice, by inhibition of AChE activity. | |
| BCN1002 | Sennoside A |
| Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine, it and Sennoside B have protective effects on gastric lesion. Sennoside A also is a new dual HIV-1 inhibitor effective on HIV-1 replication. | |
| BCN1003 | Sennoside B |
| Sennoside B, a major purgative component, has a potential utility in the treatment of proliferative diseases, through inhibiting PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway. It and sennoside A also possess significant gastroprotective activities . | |
| BCN1004 | Sennoside C |
| 1. Sennoside C , aloe-emodin anthrone and rhein anthrone which formed mainly by intraluminal bacterial action, synergistically exert their purgative effects on mice. | |
| BCN1006 | Shikonin |
| Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway. | |
| BCN1007 | Toosendanin |
| Toosendanin (TSN) was used as a digestive tract-parasiticide and agricultural insecticide in ancient China;TSN is a selective presynaptic blocker, a L-type Ca 2+ channel agonist and an effective antibotulismic agent, by interfering with neurotransmitter release through an initial facilitation followed by a subsequent depression. TSN has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-60 cells. | |
