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3',4',7,8-Tetrahydroxyflavone

CAS# 3440-24-2

3',4',7,8-Tetrahydroxyflavone

Catalog No. BCN0145----Order now to get a substantial discount!

Product Name & Size Price Stock
3',4',7,8-Tetrahydroxyflavone: 5mg Please Inquire In Stock
3',4',7,8-Tetrahydroxyflavone: 10mg Please Inquire In Stock
3',4',7,8-Tetrahydroxyflavone: 20mg Please Inquire Please Inquire
3',4',7,8-Tetrahydroxyflavone: 50mg Please Inquire Please Inquire
3',4',7,8-Tetrahydroxyflavone: 100mg Please Inquire Please Inquire
3',4',7,8-Tetrahydroxyflavone: 200mg Please Inquire Please Inquire
3',4',7,8-Tetrahydroxyflavone: 500mg Please Inquire Please Inquire
3',4',7,8-Tetrahydroxyflavone: 1000mg Please Inquire Please Inquire

Quality Control of 3',4',7,8-Tetrahydroxyflavone

Number of papers citing our products

Chemical structure

3',4',7,8-Tetrahydroxyflavone

3D structure

Chemical Properties of 3',4',7,8-Tetrahydroxyflavone

Cas No. 3440-24-2 SDF Download SDF
PubChem ID 688798 Appearance Powder
Formula C15H10O6 M.Wt 286.2
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,4-dihydroxyphenyl)-7,8-dihydroxychromen-4-one
SMILES C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O)O)O
Standard InChIKey ARYCMKPCDNHQCL-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H10O6/c16-9-3-1-7(5-12(9)19)13-6-11(18)8-2-4-10(17)14(20)15(8)21-13/h1-6,16-17,19-20H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3',4',7,8-Tetrahydroxyflavone

The herbs of Rhus succedanea L.

Biological Activity of 3',4',7,8-Tetrahydroxyflavone

Description1.
2. 3',4',7,8-Tetrahydroxyflavone exhibits antibacterial activity against S. mutans.

3',4',7,8-Tetrahydroxyflavone Dilution Calculator

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3',4',7,8-Tetrahydroxyflavone Molarity Calculator

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Preparing Stock Solutions of 3',4',7,8-Tetrahydroxyflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4941 mL 17.4703 mL 34.9406 mL 69.8812 mL 87.3515 mL
5 mM 0.6988 mL 3.4941 mL 6.9881 mL 13.9762 mL 17.4703 mL
10 mM 0.3494 mL 1.747 mL 3.4941 mL 6.9881 mL 8.7352 mL
50 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.3976 mL 1.747 mL
100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.6988 mL 0.8735 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3',4',7,8-Tetrahydroxyflavone

3',4',7,8-Tetrahydroxyflavone inhibits RANKL-induced osteoclast formation and bone resorption.[Pubmed:29442051]

Pharmazie. 2017 Mar 1;72(3):161-166.

Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-tetrahydroxyflavone is a flavonoid from Acacia confusa. In the present study, we found that 3',4',7,8-tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7,8-tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K. In addition, 3',4',7,8-tetrahydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3',4',7,8-tetrahydroxyflavone inhibited RANKL-induced expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, ectopic overexpression of a constitutively active form of NFATc1 completely rescued the anti-osteoclastogenic effect of 3',4',7,8-tetrahydroxyflavone, suggesting that the anti-osteoclastogenic effect was mainly attributed to the reduction in NFATc1 expression. Taken together, our data suggest that 3',4',7,8-tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases.

Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.[Pubmed:15659385]

J Biol Chem. 2005 Apr 8;280(14):13229-40.

Inositol-1,4,5-trisphosphate 3-kinases (IP3K) A, B, and C as well as inositol polyphosphate multikinase (IPMK) catalyze the first step in the formation of the higher phosphorylated inositols InsP5 and InsP6 by metabolizing Ins(1,4,5)P3 to Ins(1,3,4,5)P4. In order to clarify the special role of these InsP3 phosphorylating enzymes and of subsequent anabolic inositol phosphate reactions, a search was conducted for potent enzyme inhibitors starting with a fully active IP3K-A catalytic domain. Seven polyphenolic compounds could be identified as potent inhibitors with IC50 < 200 nM (IC50 given): ellagic acid (36 nM), gossypol (58 nM), (-)-epicatechin-3-gallate (94 nM), (-)-epigallocatechin-3-gallate (EGCG, 120 nM), aurintricarboxylic acid (ATA, 150 nM), hypericin (170 nM), and quercetin (180 nM). All inhibitors displayed a mixed-type inhibition with respect to ATP and a non-competitive inhibition with respect to Ins(1,4,5)P3. Examination of these inhibitors toward IP3K-A, -B, and -C and IPMK from mammals revealed that ATA potently inhibits all kinases while the other inhibitors do not markedly affect IPMK but differentially inhibit IP3K isoforms. We identified chlorogenic acid as a specific IPMK inhibitor whereas the flavonoids myricetin, 3',4',7,8-tetrahydroxyflavone and EGCG inhibit preferentially IP3K-A and IP3K-C. Mutagenesis studies revealed that both the calmodulin binding and the ATP [corrected] binding domain in IP3K are involved in inhibitor binding. Their absence in IPMK and the presence of a unique insertion in IPMK were found to be important for selectivity differences from IP3K. The fact that all identified IP3K and IPMK inhibitors have been reported as antiproliferative agents and that IP3Ks or IPMK often are the best binding targets deserves further investigation concerning their antitumor potential.

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