Lappaol B

CAS# 62359-60-8

Lappaol B

Catalog No. BCN0156----Order now to get a substantial discount!

Product Name & Size Price Stock
Lappaol B: 5mg $196 In Stock
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Quality Control of Lappaol B

Number of papers citing our products

Chemical structure

Lappaol B

3D structure

Chemical Properties of Lappaol B

Cas No. 62359-60-8 SDF Download SDF
PubChem ID 323895 Appearance Powder
Formula C31H34O9 M.Wt 550.6
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[(3,4-dimethoxyphenyl)methyl]-3-[[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]methyl]oxolan-2-one
SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC4=C(C(=C3)OC)OC(C4CO)C5=CC(=C(C=C5)O)OC)OC
Standard InChIKey KNSPNZVXPUCWMJ-UHFFFAOYSA-N
Standard InChI InChI=1S/C31H34O9/c1-35-25-8-5-17(12-27(25)37-3)9-20-16-39-31(34)21(20)10-18-11-22-23(15-32)29(40-30(22)28(13-18)38-4)19-6-7-24(33)26(14-19)36-2/h5-8,11-14,20-21,23,29,32-33H,9-10,15-16H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lappaol B

The roots of Gymnadenia conopsea

Biological Activity of Lappaol B

DescriptionReference standards.

Lappaol B Dilution Calculator

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Lappaol B Molarity Calculator

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Preparing Stock Solutions of Lappaol B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8162 mL 9.081 mL 18.162 mL 36.324 mL 45.405 mL
5 mM 0.3632 mL 1.8162 mL 3.6324 mL 7.2648 mL 9.081 mL
10 mM 0.1816 mL 0.9081 mL 1.8162 mL 3.6324 mL 4.5405 mL
50 mM 0.0363 mL 0.1816 mL 0.3632 mL 0.7265 mL 0.9081 mL
100 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.3632 mL 0.4541 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lappaol B

Anti-austeric activity of phenolic constituents of seeds of Arctium lappa.[Pubmed:23738454]

Nat Prod Commun. 2013 Apr;8(4):463-6.

From seeds of Arctium lappa L. (Asteraceae) we obtained arctigenin (1), arctiin (2), chlorogenic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5), 3,4-dicaffeoylquinic acid (6), matairesinol (11), isolappaol A (12), lappaol F (14), and Lappaol B (15), together with 1:1 mixtures of isolappaol C (7) and lappaol C (8), arctignan E (9) and arctignan D (10), and 12 and lappaol A (13), while 3,3',4'-tri-O-demethylarctigenin (16), 3,3'-di-O-demethyl-4'-dehydroxyarctigenin (17), and 3-O-demethylarctigenin (18) were obtained by anaerobic microbiological metabolism of 1. Then, we evaluated the in vitro preferential cytotoxic activity of these pure compounds and 1:1 mixtures, together with enterodiol (19) and enterolactone (20), against human pancreatic cancer PANC-1 cells in nutrient-deprived medium (NDM). Among them, 1 and 18 showed potent activity, with PC50 values of 1.75 and 4.38 microM, respectively, while 11, 15, and 17 showed mild activity with PC50 values of 31.1, 30.9, and 38.7 microM, respectively. By comparing their structures and PC50 values, the following structural moieties could be concluded to be important for the preferential cytotoxicity of 1: 1) the 3-hydroxy-4-methoxyphenyl group at the 2-position on the gamma-butyrolactone ring, 2) the less polar substituent at the 3-position on the gamma-butyrolactone ring, and 3) the gamma-butyrolactone ring.

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