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3-O-(2'E,4'E-Decadienoyl)ingenol

CAS# 466663-11-6

3-O-(2'E,4'E-Decadienoyl)ingenol

Catalog No. BCN3768----Order now to get a substantial discount!

Product Name & Size Price Stock
3-O-(2'E,4'E-Decadienoyl)ingenol: 5mg Please Inquire In Stock
3-O-(2'E,4'E-Decadienoyl)ingenol: 10mg Please Inquire In Stock
3-O-(2'E,4'E-Decadienoyl)ingenol: 20mg Please Inquire Please Inquire
3-O-(2'E,4'E-Decadienoyl)ingenol: 50mg Please Inquire Please Inquire
3-O-(2'E,4'E-Decadienoyl)ingenol: 100mg Please Inquire Please Inquire
3-O-(2'E,4'E-Decadienoyl)ingenol: 200mg Please Inquire Please Inquire
3-O-(2'E,4'E-Decadienoyl)ingenol: 500mg Please Inquire Please Inquire
3-O-(2'E,4'E-Decadienoyl)ingenol: 1000mg Please Inquire Please Inquire
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Quality Control of 3-O-(2'E,4'E-Decadienoyl)ingenol

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Chemical structure

3-O-(2'E,4'E-Decadienoyl)ingenol

3D structure

Chemical Properties of 3-O-(2'E,4'E-Decadienoyl)ingenol

Cas No. 466663-11-6 SDF Download SDF
PubChem ID 101423531 Appearance Powder
Formula C30H42O6 M.Wt 498.7
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCCCCC=CC=CC(=O)OC1C(=CC23C1(C(C(=CC(C2=O)C4C(C4(C)C)CC3C)CO)O)O)C
Standard InChIKey XMXZQPNIMGCMHC-WEKWZCEWSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-O-(2'E,4'E-Decadienoyl)ingenol

The roots of Euphorbia kansui T. N. Liou ex S. B. Ho

Biological Activity of 3-O-(2'E,4'E-Decadienoyl)ingenol

Description1. 3-O-(2'E,4'E-Decadienoyl)ingenol , one toxic terpenoid from raw Gansui. 2. 3-O-(2′E,4′E-decadienoyl)-ingenol and 3-O-(2′E,4′Z-decadienoyl)-20-O-acetyl-ingenol show cytotoxicity on Namalwa cells with IC 50 values of 7.6 and 5.2 umol·L-1, respectively.

3-O-(2'E,4'E-Decadienoyl)ingenol Dilution Calculator

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3-O-(2'E,4'E-Decadienoyl)ingenol Molarity Calculator

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Preparing Stock Solutions of 3-O-(2'E,4'E-Decadienoyl)ingenol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0052 mL 10.0261 mL 20.0521 mL 40.1043 mL 50.1303 mL
5 mM 0.401 mL 2.0052 mL 4.0104 mL 8.0209 mL 10.0261 mL
10 mM 0.2005 mL 1.0026 mL 2.0052 mL 4.0104 mL 5.013 mL
50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8021 mL 1.0026 mL
100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-O-(2'E,4'E-Decadienoyl)ingenol

Diterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus.[Pubmed:12350140]

J Nat Prod. 2002 Sep;65(9):1246-51.

Twelve polycyclic diterpenes have been isolated from the roots of Euphorbia kansui. Nine were assigned with an ingenol skeleton, 20-O-(2'E,4'E-decadienoyl)ingenol (1), 20-O-(2'E,4'Z-decadienoyl)ingenol (2), 3-O-(2'E,4'Z-decadienoyl)ingenol (3), 3-O-(2'E,4'E-decadienoyl)ingenol (4), 3-O-(2'E,4'Z-decadienoyl)-5-O-acetylingenol (5), 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol (6), 3-O-(2'E,4'E-decadienoyl)-20-O-acetylingenol (7), 20-O-(decanoyl)ingenol (8), and 5-O-(2'E,4'E-decadienoyl)ingenol (9), and three with a jatrophane skeleton, kansuinins A (12), B (11), and C (10). Compounds 1, 2, 5, 9, and 12 are new compounds, while 4 and 7 were assigned with new geometric configurations. Their structures were elucidated by spectroscopic and chemical analysis. In vitro treatment of cultured individual Xenopus cells at the blastular stage with 1-9 arrested cleavage significantly (0.5 microg/mL of each compound resulted in >75% cleavage arrest). Of the three jatrophane diterpenes (10-12), only kansuinin B (11) showed any activity, resulting in 87% cleavage arrest at 50 microg/mL.

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