5-Methyl-2-furaldehyde

The rhizome of Typhonium giganteum Engl.

Vortex- and CO2 -gas-assisted liquid-liquid microextraction with salt addition for the high-performance liquid chromatographic determination of furanic compounds in concentrated juices and dried fruits.[Pubmed:26718308]

J Sep Sci. 2016 Mar;39(5):947-55.

A novel microextraction method based on vortex- and CO2 -assisted liquid-liquid microextraction with salt addition for the isolation of furanic compounds (5-hydroxymethyl-2-furaldehyde, 5-Methyl-2-furaldehyde, 2-furaldehyde, 3-furaldehyde, 2-furoic and 3-furoic acids) was developed. Purging the sample with CO2 was applied after vortexing to enhance the phase separation and mass transfer of the analytes. The optimum extraction conditions were: extraction solvent (volume), propyl acetate (125 muL); sample pH, 2.4; vortexing time, 45 s; salt concentration, 25% w/v and purging time, 5 min. The analytes were separated using an ODS Hypersil C18 column (250x4.6 mm i.d, 5 mum) under gradient flow. The proposed method showed good linearities (r(2) >0.999), low detection limits (0.08-1.9 mug/L) and good recoveries (80.7-122%). The validated method was successfully applied for the determination of the furanic compounds in concentrated juice (mango, date, orange, pomegranate, roselle, mangosteen and soursop) and dried fruit (prune, date and apricot paste) samples.

Quantification of furanic derivatives in fortified wines by a highly sensitive and ultrafast analytical strategy based on digitally controlled microextraction by packed sorbent combined with ultrahigh pressure liquid chromatography.[Pubmed:25618358]

J Chromatogr A. 2015 Feb 13;1381:54-63.

An improved, reliable and powerful analytical strategy based on digitally controlled microextraction by packed sorbent (MEPS) combined with ultrahigh pressure liquid chromatography (UHPLC) was validated for the simultaneous identification and quantification of major furanic derivatives, namely 5-hydroxymethyl-2-furaldehyde (5HMF), 5-Methyl-2-furaldehyde (5MF), 2-furaldehyde (2F) and 2-furyl methyl ketone (2FMK), in fortified wines. To enhance the extraction efficiency of the target furanic derivates, several influencing extraction parameters, such as number of loading cycles, nature of elution solvent and elution volume, were evaluated and optimized. In addition the ability of different MEPS sorbent materials, namely C2, C8, C18, SIL, M1, R-AX, R-CX and PGC, were also tested. The optimal analytical conditions involved loading 3x200 muL of wine samples through a C8 sorbent in a MEPS syringe placed in the semi-automatic eVolH syringe followed by elution using 200 muL MeOH:H2O (95:5, v/v). The furanic derivates separation was achieved using a CORTECS UPLC((R)) C18 analytical column in an ultrafast chromatographic run (within 4 min). The method performance was assessed for dry/medium dry (D/MD) and sweet/medium sweet (S/MS) model wines in terms of selectivity, linearity, limit of detection (LOD), limit of quantitation (LOQ), accuracy, precision and matrix effect, using model wine matrix-matched calibration. Good linearity was obtained with a regression coefficient (r(2)) higher than 0.992. A good precision was attained (RSD<5%) and low LODs were achieved for D/MD (4.5-129.3 ng L(-1)) and S/MS (6.9-285.2 ng L(-1)) model wines. The quantification limits (LOQ) for D/MD model wines ranged from 14.9 to 431.0 ng L(-1), whereas for S/MS model wines range from 23.1 to 950.5 ng L(-1). The method also afforded satisfactory results in terms of accuracy, ranging from 74 to 97% for D/MD wines and between 84 and 99% for S/MS wines. The MEPS(C8)/UHPLC-PDA analytical strategy was successfully applied to analyze furanic derivates in 26 fortified Madeira wines from different types (D/MD, S/MS) and ages. The obtained results revealed the analytical strategy as a suitable tool which combines sensitivity, effectiveness, reduced analysis time and simple analytical procedure. Principal component analysis (PCA) suggested that fortified wines can be organized based on their age on PC1, which are mainly characterized by 5HMF.

5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa. A flavoring agent.

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